49ers key matchup No. 1: Kaepernick vs. Wilson

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Editor's note: This is the final part in a series that spotlights three 49ers-Seahawks matchups to watch Sunday, 5:20 p.m. (NBC-TV), at CenturyLink Field, Seattle

[RELATED: 49ers key matchup No. 2: Jean Francois vs. McQuistan]

[RELATED: 49ers key matchup No. 3: Crabtree vs. Sherman]

49ers QB Colin Kaepernick vs. Seattle QB Russell Wilson

Tale of the tape
Kaepernick (7): 6-foot-4, 230 pounds, second season, Nevada
Wilson (3): 5-foot-11, 206 pounds, rookie, Wisconsin

The 49ers saw Russell Wilson at his worst earlier this season. The Seattle Seahawks have yet to see Colin Kaepernick.

The two dual-threat quarterbacks will meet for the first time Sunday night when the 49ers and Seahawks meet in an NFC West matchup that could be a preview of a playoff meeting next month. And it could be the first of many meetings with Kaepernick and Wilson running their respective offenses over the coming seasons.

But Kaepernick's mind is not on the future. It's on tonight's game.

"He'll be my adversary Sunday night," Kaepernick said. "That's what we're worried about."

The 49ers are 4-1 since Kaepernick stepped into the lineup to replace Alex Smith, who sustained a concussion and was demoted once he got healthy. Kaepernick is completing 65.6 percent of his pass attempts with seven touchdowns and two interceptions. His passer rating is 101.3. Kaepernick is also the 49ers' second-leading rusher with 379 yards and five touchdowns.

Kaepernick has already gotten the better of his road meetings against New Orleans' Drew Brees and New England's Tom Brady. Kaepernick was named NFC Offensive Player of the Week for his four-touchdown performance last week in a 41-34 victory over the Patriots.

Meanwhile, Wilson has come on strong in his rookie season. The third-round draft pick has thrown 21 touchdowns and nine interceptions with a 95.5 passer rating. He has rushed for 409 yards, as the Seahawks have incorporated more quarterback runs into the offense since their Oct. 18 meeting at Candlestick Park.

Wilson completed just 9 of 23 passes for 122 yards and an interception in the 49ers' 13-6 victory earlier this season. Wilson had three rushing attempts for 10 yards in that game.

"The biggest difference they're doing since we last played them is they've installed the gun-read game into their offense and they're doing it a lot," 49ers defensive coordinator Vic Fangio said. "They had shown it very sparingly prior to the last game. Now they're doing it a lot.

"And the quarterback's just gotten better and better, as you'd expect a rookie quarterback to do. He's no longer a rookie. This is his 15th pro start. So, he's really a good quarterback. He's very elusive, he's fast, got good command of their offense, throws the deep stuff well and he's been a great acquisition for them."

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