Former 49ers offensive guards Mike Iupati and Alex Boone have been ruled out for Sunday’s game against their old team, Cardinals coach Bruce Arians told the Arizona media on Friday.
The 49ers (0-3) play the Cardinals (1-2) on Sunday in Glendale, Arizona. Iupati will undergo surgery on his elbow and will be placed on injured reserve, Arians said. Boone is expected to miss a couple of weeks with a pectoral injury.
Iupati started the Cardinals’ season opener at left guard. Boone took over at left guard after Iupati’s injury and started the past two games.