If protecting Tom Brady is your No. 1 concern, then you'll consider this worthy of note: The Patriots are on to their third starting right tackle.
LaAdrian Waddle suffered an ankle injury against the Dolphins last week and has been ruled out for Sunday's game with the Bills. Waddle tested the ankle on Friday and again on Sunday before the game, but he was deemed unable to play. In his absence, Cam Fleming is the likely starter on the right side opposite Nate Solder.
The Patriots may have caught a break given the opponent. The Bills have just 17 sacks on the season, the second-lowest total in the NFL.
Joining Waddle on the inactive list are Matthew Slater (hamstring), Trey Flowers (ribs), Trevor Reilly (concussion), Marcus Cannon (ankle) and Chris Hogan (shoulder). Mike Gillislee is a healthy scratch yet again.
The Patriots will have David Andrews back in the lineup for the first time since spending a week in Colorado to prep for their game in Mexico City. He missed two weeks with an illness.