DENVER (AP) Peyton Manning threw five touchdown passes - two to his newest target, Wes Welker - to help the Denver Broncos build a 35-17 lead over Super Bowl champion Baltimore after three quarters Thursday night in the season opener that started 33 minutes late because of lightning.
This marks the seventh time in Manning's career he has thrown for that many scores in a game. It ties Drew Brees of New Orleans for most in NFL history.
The four-time NFL MVP was 22 of 35 for 315 yards. He threw two TD passes each to Welker and tight end Julius Thomas, along with another to Andre Caldwell.
Manning found Caldwell for a 28-yard score on the opening drive of the second half and then located Welker for a 5-yard TD moments later. The Welker score was set up when David Bruton blocked a punt by Sam Koch, giving Denver the ball deep in Baltimore territory.
Midway through the third quarter, Welker and Manning teamed up again as the Broncos outscored the Ravens 21-0 in the third quarter.
Justin Tucker gave the Ravens a 17-14 lead at the break with a 25-yard field goal.
Manning and Thomas hooked up for a pair of touchdowns in the first half. Thomas entered the game with no career TDs and just one catch. He has five catches for 110 yards through three quarters.
The third-year player out of Portland State was in uniform despite the revelation earlier in the day of an arrest that occurred last week. Thomas had been stopped for speeding on Aug. 28 and was then arrested for failing to appear in court for a traffic citation earlier this year.
Ray Rice scampered in for a 1-yard touchdown early in the second quarter to give the Ravens a 14-7 lead. Rice's short TD score was set up when Welker muffed a punt near the goal line, the ball slipping through his hands on a fair catch. Morgan Cox pounced on the ball as Welker tried to haul it back in.
In the opening quarter, Joe Flacco threw a 2-yard TD pass to fullback Vonta Leach.
Manning tied it at 7 in the second quarter when he tossed a 24-yard TD pass to Thomas. That came right after Chris Harris' diving interception. It was Flacco's first interception in 210 attempts. Flacco's last interception also was by Harris.
The Ravens nearly had a special teams breakdown when Jacoby Jones tried to fair catch a punt, only to have a teammate collide with him. But the ball didn't touch either of the players. It was costly, though, as Jones sprained his knee and was doubtful to return.
The temperature at kickoff was 83 degrees, a drastic change from when Baltimore and Denver met at Mile High in January for a playoff game. Back then, the temperature was 13 degrees as the Ravens ended the Broncos' season 38-35 in double overtime.
Just like in the playoff game, Manning wore a glove on his throwing hand for a better grip. He abandoned it in the second quarter.
Manning found Welker eight times for 61 yards.
Usually, the Super Bowl champs open at home. But there was a conflict in Baltimore with baseball's Orioles playing at home and so the game was switched to the Mile High City.
Greeting Broncos fans as they entered Mile High was a gigantic banner of Flacco alongside Manning. The presence of the poster created quite an uproar around town for the last several weeks.
Elvis Dumervil made his return to Denver as a member of the Ravens and was booed when his name was announced. The linebacker was all set to agree on a new deal with the Broncos in the offseason when a fax foul-up prevented that from happening and the team cut him to save money.
Dumervil and Von Miller called themselves "Doom & Gloom" while in Denver, combining combined for 29 1/2 of the Broncos' league-leading 52 sacks in 2012.
Miller wasn't on the field, either, as the Pro Bowl linebacker began serving his six-game suspension for violating the league's drug abuse policy. The Broncos also were without cornerback Champ Bailey, who's hobbled by a sprained left foot.
AP NFL website: www.pro32.ap.org