Tramaine Isabell scored 22 points to lead five Dragons in double figures, made 11 of 14 free throws and handed out five assists as Drexel pulled away early from Division III member Arcadia University to win 95-81 on Monday night.
Troy Harper added 17 points and grabbed eight rebounds, Sammy Mojica added 13 points with five assists, Kurk Lee had 11 points, and Austin Williams, 10 for Drexel (2-0).
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Arcadia's Josh Scott tied it at 2 with a layup, but Drexel quickly pulled ahead on a 10-3 run in which Jarvis Doles made a 3 and led 51-42 at halftime behind Harper's 15 points and on 55.2 percent shooting from the floor.
The Dragons shot 58.8 percent early in the second half and led 81-60 after Isabell hit a pair of free throws, and cruised.
Da'Kquan Davis scored 18 points for the Knights, who play in the Mid Atlantic Conference. Josh Scott and Brandon Thompson scored 14 apiece, with Thompson shooting 4 of 8 from 3-point range, and Phil Pierfy added 13 points.
It was the first meeting of the teams.