Jarrod Simmons scored 12 points to lead five Pennsylvania players in double figures and the Quakers made 14 3-pointers in their 105-52 rout of Delaware State on Wednesday night.
It's the first time Penn has topped 100 points since the 2005-06 season.
Caleb Wood scored 11 points and Antonio Woods, Max Rothschild and Devon Goodman added 10 apiece for Penn (9-4), which shot 61.4 percent from the field (35 of 57) and 51.9 percent from 3-point range.
Ten different Penn players hit at least one 3-pointer and all 15 who suited up scored at least 3 points. Penn outscored Delaware State 40-22 in the paint and 22-2 on fast breaks and got 22 points off of 14 Hornets turnovers.
Ryan Betley's 3 put Penn up for good, 3-2, and sparked a 23-4 run en route to a 55-24 halftime lead after shooting 65.5 percent from the field. Ray Jerome's 3 with 3:01 left gave Penn its largest lead at 56 points.
Jonathan Walker scored 10 points for Delaware State (2-13), which has lost nine straight.
AJ Brodeur scored 18 points with nine rebounds and six assists and Penn defeated Cornell 69-61 on Friday night, beating the Big Red for the 10th consecutive time.
Ryan Betley added 13 points and Darnell Foreman 12, including three free throws in the final minute for Penn (11-5, 1-1 Ivy League), which has won six of its last seven.
Stone Gettings scored 20 points and grabbed a career-high 17 rebounds for the Big Red (6-8, 0-1) with Matt Morgan adding 13 points, his 37th straight double-figure game.
After Brodeur opened the second half with a bucket, Gettings scored the next 10 points, including a pair of 3-pointers, to get Cornell within two. A 10-0 run built a 14-point cushion for the Quakers with five minutes left before the Big Red made a final push, getting within four with 53 seconds remaining. Foreman drew a charge in the final minute and made 3 of 4 free throws to ensure the win.
The teams were tied in the first half when Max Rothschild scored four straight points to start an 18-3 run and a 31-16 lead that Cornell cut to 34-24 at the break.
Ryan Betley scored 21 points and grabbed five rebounds to lead five players in double-figure scoring as Penn beat Princeton 76-70 in an Ivy League opener on Saturday.
Betley was 8 of 11 including three from distance for the Quakers (10-5). Antonio Woods added 13 points and four rebounds, AJ Brodeur had 12 points and eight rebounds, Darnell Foreman had 11 points and Max Rothschild added 10 points with six rebounds and five assists.
Betley scored 19 points in the first half, helping to lift Penn to a 36-27 lead at the break.
The Quakers led throughout the second half. Princeton cut it to 72-70 with 50 seconds to play but Brodeur sank a jumper after that and Woods drained a pair of free throws to secure the win.
Devin Cannady led the Tigers (7-8) with 21 points. Amir Bell added 12.