CARSON, Calif. — Isaac Seumalo began the season as the Eagles' starter at left guard. Now he's not even active.
Seumalo was the surprise member of the Eagles' inactives list on Sunday. Stefen Wisniewski will likely start at left guard, while Chance Warmack might rotate in.
This is the first time since the seventh game of his rookie season in 2016 that Seumalo is inactive. He was inactive for the first seven games of his NFL career but has been up every game since then.
Fletcher Cox (calf), Ronald Darby (ankle), Jaylen Watkins (hamstring), Corey Graham (hamstring) and Destiny Vaeao (wrist) were all ruled out on Friday and join Seumalo on the inactive list.
The other healthy inactive is rookie wideout Shelton Gibson.
Two defensive linemen -- Steven Means and Justin Hamilton -- are active for the first time this year.
With Cox and Vaeao ruled out, the Eagles signed Hamilton off their practice squad on Saturday. This will be the first career game for Hamilton and the first game of the season for Means.
Means was praised by the coaching staff throughout training camp and was even given a contract extension. But he has been inactive through the first three games of the season.
Even with Hamilton on the roster and active, it's very possible the Eagles will use defensive ends Vinny Curry and Brandon Graham inside at times on Sunday.
Chargers inactives: QB Cardale Jones, S Dexter McCoil, LB Nick Dzubnar, T Tyler Marz, TE Sean Culkin, WR Mike Williams, DE Jerry Attaochu.