Derrick Gunn makes his picks for Week 3 of the NFL season.
Giants at Eagles (1 p.m. on FOX)
Both the Eagles and Giants have good defensive fronts. Both Carson Wentz and Eli Manning are going to get hit, Manning probably a lot more. The Giants have no run game and their offensive line is a mess. Odell Beckham Jr. is not at 100 percent health-wise but is expected to play. Speaking of health, the Eagles' secondary is a mash unit right now. Ronald Darby is on the shelf for a few more weeks, but three additional DBs could sit this one out. Will the Eagles commit to the run game? Don't count on it. The Giants could be without their best cover corner in Janoris Jenkins, who missed the G-men's Monday night loss Detroit. New York head coach Ben McAdoo said they will make changes to a lethargic offense, so the Eagles must expect the unexpected. This game could be closer than it should be, with the Eagles pulling away down the stretch.
Pick: Eagles 23, Giants 13
Ravens at Jaguars in London (9:30 a.m. on Yahoo!)
The Ravens are playing solid defense, while it's hard to figure out the Jaguars. Jacksonville's defense got 10 sacks in the season opener, then got smacked by Tennessee last Sunday. The Jags hold the edge over the Ravens in overseas trips five to zero, but that's about it. The Ravens will go to 3-0.
Broncos at Bills (1 p.m. on CBS)
Wow, looks like Broncos QB Trevor Siemian has grown up. He's been accurate and has command of the offense. The Bills will have trouble moving the ball against a stingy defense. Like Sergio Dipp said, Broncos coach Vance Joseph is having the time of his life, and so will his team against the Bills.
Steelers at Bears (1 p.m. on CBS)
The Steelers are off to a great start. The Bears wish they could start the season over. The way the $18-million-man Mike Glennon is playing, he could be benched before the halfway point of the season. The Steelers will remain undefeated, while "Da Bears" stay winless.
Falcons at Lions (1 p.m. on FOX)
A shootout special: Matt Ryan vs Matthew Stafford. You expect it from their offense, but the Lions' defense is also balling with six sacks, four interceptions and three forced fumbles. The Falcons' defense is no slouch with seven sacks. Defense will have to take a back seat in what could be a game with plenty of offensive fireworks. I like the Lions in a mild upset over the defending NFC champs.
Browns at Colts (1 p.m. on CBS)
I'm glad I don't have to pay good money to see this mess between two winless teams. Until the Colts get Andrew Luck back, their season is an exercise in futility. Jacoby Brissett will try to get the Colts in the win column, but DeShone Kizer and Cleveland have other ideas. The Colts drop to 0-3.
Bucs at Vikings (1 p.m. on FOX)
Both teams are similar in that they have plenty of talent on both sides of the ball. The difference is Tampa Bay has a healthy Jameis Winston and Minnesota has Sam Bradford dealing with a knee injury. Even if Bradford plays I'm not sure he'll hold up against the Bucs' pass rush. Tampa scores a road decision.
Texans at Patriots (1 p.m. on CBS)
Don't send a rookie QB into Foxborough to face Bill Belichick, because he's never lost to a first-year QB at home. It will be a good learning experience for the Texans and young QB Deshaun Watson, but the Pats will roll.
Dolphins at Jets (1 p.m. on CBS)
It's sad days for Jets fans, as they watch their team with little talent and no hope for 2017. Through two weeks, the Jets have given up a league-high 66 points. Enough said.
Saints at Panthers (1 p.m. on FOX)
The Panthers' defense has given up just six points and looks like their top-10 defense of 2015. The Saints have had a brutal schedule, losing to both the Vikings and Pats. This time, the Panthers will rise in the NFC South.
Seahawks at Titans (4:05 p.m. on FOX)
Both teams are playoff-caliber squads, but the Seahawks have put out an APB on their missing offense. The Titans' power run game vs. the Hawks rock 'em sock 'em D. Remember the Titans at home.
Bengals at Packers (4:25 p.m. on CBS)
The Bengals' offense has yet to score a TD while the Packers' D was very generous in Atlanta. The Bengals have offensive line issues, while the Packers have health issues across the board. But the home team still has Aaron Rodgers standing tall. The Pack gets back in the win column.
Chiefs at Chargers (4:25 p.m. on CBS)
It's like Groundhog Day for the Chargers. Last year, they couldn't win a lot of close games. This year, they've lost by margins of three and two points. Big Red returns to his hometown and puts a jolt into the Chargers' hopes of pulling off an upset.
Raiders at Redskins (8:30 p.m. on NBC)
The 'Skins are feeling good coming off a win, but the Raiders — who have scored a league-high 71 points — can leave a team ill in a hurry. Kirk Cousins is still trying to find his groove in the passing game. Derek Carr won't have that problem. The Raiders roll on the road.
Cowboys at Cardinals (8:30 p.m. Monday on ESPN)
The Cowboys got roughed up by Denver. The Cardinals had to sweat out an OT win against Indy. Are the Cards starting to show their age? Dez Bryant vs. Patrick Peterson should be a fun matchup to watch. 'Zona's home opener should send the desert crowd home happy.