Derrick Gunn makes his picks for Week 13 of the NFL season.
Eagles at Seahawks, 8:30 p.m. on NBC
Now we get to a game that means something. After four weeks of watching the Birds blow out lesser competition, they step up in a challenge against a foe that knows how to prepare for big encounters. The Seahawks have been to the playoffs five years in a row, including two Super Bowl appearances. The 'Hawks are hurting on defense — Richard Sherman is out for the year, Kam Chancellor has a neck injury and Cliff Avril is out, as well. But Seattle still has that guy Russell Wilson, who has thrown for 23 touchdown passes this year — 15 of them have come in the last six games. Wilson is the master of the scramble drill and he has a versatile group of talented receivers. It will be interesting to see how the Eagles' secondary matches up with their personnel.
Carson Wentz and his offense will be thoroughly tested by the Seahawks' defensive scheme. If the Birds can get their run game going, it will take a lot of pressure off Wentz in the passing game. A win for the Eagles in the loudest stadium in the NFL will go a long way in terms of preparing them for what's to come in the postseason. So many different ways this one could go, but I'm going with a hunch that Wentz learned some valuable lessons about how to play in that environment last year, and because this team is on a roll right now, I'll say ...
Pick: Eagles 23, Seahawks 20
Vikings at Falcons, 1 p.m. on FOX
You want offense and defense? This matchup has both. The Vikings have the No. 5 offense and No. 5 defense. The Falcons have the No. 6 offense and No. 10 defense. The Vikings are riding a seven-game win streak. The Falcons have amped up their scoring during their three-game win streak. Home field is huge in this clash, so I'll go with the home team.
Patriots at Bills, 1 p.m. on CBS
Tom Brady vs. the Bills' defense is a great headline. Over his last five games, Brady, the ageless wonder, has 13 TD passes and just one interception. If the Bills can establish a run game and control the clock, they'll keep it close, but the Pats will notch their eighth straight win.
49ers at Bears, 1 p.m. on CBS
Niners QB Jimmy Garoppolo will make his first start with his new team. Bears rookie QB Mitchell Trubisky makes his eighth start, hoping his outing this time is much better than what happened to him in Philly. Based on the Bears' defense, SF will lose its 11th game.
Buccaneers at Packers, 1 p.m. on FOX
After getting blanked by Baltimore, the Pack went on the road and put a scare into the Steelers. Meanwhile, the Bucs are just playing out the season. The Pack will attack at Lambeau.
Texans at Titans, 1 p.m. on CBS
The Texans keep losing players weekly. The Titans are still thinking about winning the division. Marcus Mariota and his crew put it all together against the unraveling Texans.
Broncos at Dolphins, 1 p.m. on FOX
Trevor Siemian gave way to Paxton Lynch, who now has a high ankle sprain, so once again, it's back to Siemian. The Dolphins' defense has major flaws but maybe the return of Jay Cutler can jump-start the offense and take some pressure off the D. Dolphins get a slight nod.
Chiefs at Jets, 1 p.m. on CBS
It's amazing that the Chiefs, losers of three straight and five of their last six, are still on top of the AFC West. K.C.'s big-play offense has been a big dud. Jets head coach Todd Bowles is fighting to keep his job. His guys haven't quit on him. Chiefs have no choice but to get their offense on track. It comes together for them this week.
Colts at Jaguars, 1 p.m. on CBS
Earlier this season, the Jags shut out the Colts in Indy. This time, on their home turf, the Jags' No. 1 defense and No. 1 run offense will overwhelm the hapless Colts.
Lions at Ravens, 1 p.m. on FOX
If the playoffs were to start today, the Ravens would be in and the Lions would be out. The strength of the Ravens is their defense: No. 1 in interceptions (18) and No. 2 in points allowed (17 points per game). When Matthew Stafford is on, the Lions' offense can rack up points. Terrell Suggs and his defensive mates will be ready.
Browns at Chargers, 4:05 p.m. on CBS
I never thought I'd be saying this, but keep an eye on the Chargers. Philip Rivers has five TDs and zero INTs in his last two games and the Chargers' defense is making plays. As for Cleveland? Well, they are still the Browns. The Chargers win their third straight.
Giants at Raiders, 4:25 p.m. on FOX
Giants fans are in an uproar about the way Eli Manning was benched. The Giants aren't going anywhere but home at season's end and Geno Smith is not the future. The Raiders have issues at WR, but Derek Carr will find a way to get it done.
Panthers at Saints, 4:25 p.m. on FOX
A showdown in the NFC South. The Saints hold the division lead and the Panthers want it. Drew Brees is backed by a pair of talented RBs. The Panthers will go as far as Superman Cam Newton can take them. The Saints beat the Panthers earlier this season and they'll make it a season sweep.
Rams at Cardinals, 4:25 p.m. on FOX
The Rams are flying high after last week's win over the Saints. The Cardinals are tough on their home turf. The Cards still remember how the Rams embarrassed them earlier this season. Blaine Gabbert is the Cards' third starting QB of the season. Jared Goff and the Rams have something special going. They will tally their ninth win.
Steelers at Bengals, 8:30 p.m., Monday night on ESPN
Everyone keeps talking about the Steelers' matchup in two weeks with New England but the Steelers aren't biting. They are focused in on their division rivals, the Bengals. Anything can happen when these two get together, but the talent level this time is clearly on the Steelers' side.