Kurk Lee and Sammy Mojica combined for 42 points as Drexel jumped out to an early lead and then held off La Salle for a 72-70 victory on Thursday night.
Drexel (5-4) cruised to a 43-30 halftime advantage before La Salle rallied late. Isiah Deas scored eight straight unanswered points to pull the Explorers to 67-65 with 3:52 remaining in the game.
Lee had a free throw and a layup and Austin Williams added a jumper for a 72-68 lead with 1:40 left. La Salle's B.J. Johnson made two free throws for the final score. Deas missed a 3-point attempt as time expired.
Lee nailed 4 of 5 from beyond the arc and finished with 23 points with Mojica adding 19. Austin Williams added 16 points with seven rebounds for Drexel, which had lost three straight before flipping it to a three-game winning streak.
Johnson had has fifth double-double of the year with 21 points and 11 rebounds for La Salle (5-5).
Villanova's impressive Thanksgiving weekend was enough for the Wildcats to move up a spot in Monday's AP poll, from No. 5 to No. 4.
After rallying from 15 points down to beat Tennessee in the Battle 4 Atlantis semifinals, Villanova, led by junior guards Jalen Brunson and Mikal Bridges, dominated Northern Iowa 64-50 in Friday's final to take home the tournament title.
Aiding 'Nova's effort to move up was the poor week from previous No. 2 Arizona, which lost all three of its games in the Battle 4 Atlantis and dropped out of the Top 25.
Duke (8-0) stayed at No. 1 in the nation, receiving all 65 AP votes after two big comeback wins against Texas and then-No. 7 Florida led the Blue Devils to the Pk80 Invitational's Motion Bracket title.
Kansas climbed to No. 2 after beating Texas Southern and Oakland to stay at 5-0, while Michigan State and Notre Dame each moved up a spot to No. 3 and No. 5, respectively.
On Monday, Villanova and Kansas announced a home-and-home series the storied programs will play over the next two seasons.
B.J. Johnson had 30 points and 10 rebounds to help La Salle beat South Alabama 81-73 on Thursday night.
La Salle led 65-44 midway through the second half until South Alabama scored 14 straight. Johnson ended the run with a put-back basket to make it 67-58 with 7:03 left.
Rodrick Sikes pulled South Alabama within 78-73 but Amar Stukes answered with a 3-pointer with 1:04 left.
La Salle (3-0) opened the game with 10 unanswered points and led 47-27 at halftime. Johnson scored nine of La Salle's first 18 points as it held a 10-point lead. He had 22 points and six rebounds at the break.
Johnson, coming off a 20-point and career-high 14-rebound performance, had his third straight double-double. Isiah Deas added 15 points, and Saul Phiri had 14 points and 10 rebounds.
The Explorers held their previous two opponents to below 35 percent shooting but the Jaguars were 26-of-55 shooting.
Jordan Andrews made four 3-pointers and scored 20 points for South Alabama (1-2), which played La Salle for the first time in program history. Sikes added 17 points, Herb McGee had 12, and Josh Ajayi 10.