Karekin Brooks had 10 carries for 142 yards and two touchdowns to help Pennsylvania beat Division II Ohio Dominican 42-24 on Saturday in the Quakers' season opener.
Will Fischer-Colbrie threw for 198 yards and two scores, and Justin Watson had eight receptions for 134 yards and two touchdowns.
On the first drive of the third quarter, Fischer-Colbrie threw for a 2-yard score to Watson to cap a 7-play, 65-yard drive, giving to Penn the lead for good at 14-10. Three-plus minutes later, Brooks scored from 18-yards out to make it 21-10 and Nicholas Bokun scored on a 30-yard reception at the 6:12 mark for an 18-point lead.
Grant Russell threw for 273 yards and two scores for Old Dominican (0-3).
The Panthers took an early 7-0 lead on Cedric Washington's 40-yard touchdown reception with 9:22 left in the first quarter to cap a seven-play, 79-yard drive.
The Quakers played their 1,374th game, the most of any program at any level of college football.