While injuries often influence a team's season, 12th-ranked Villanova has been especially challenged in recent weeks.
On Monday, the Wildcats were awaiting MRI results for quarterback Zach Bednarczyk, who suffered a knee injury early in a 24-9 win at Towson on Saturday night.
It occurred one game after senior safety Rob Rolle, the CAA Football preseason defensive player of the year, suffered an ACL injury and was lost for the remainder of the season. Two other starters, tight end Ryan Bell and running back Matt Gudzak, also were injured in that loss to Albany and missed the Towson game.
Earlier last month, top wide receiver Changa Hodge was lost to a season-ending foot injury.
"It's been difficult. We don't have a huge roster as it is," first-year coach Mark Ferrante said Monday. "When you lose guys of that magnitude, it's never an easy thing and it's always going to be a challenge.
"Unfortunately, we're playing a lot of first-year players. Not just redshirt freshmen, but we're playing probably more true freshmen than we anticipated playing and had to take some redshirts off from guys. I'm sure that will gain them some valuable experience and things for down the road. But we've got to try to do the best we can in the present."
Bednarczyk, a 2 1/2-year starter, has been one of the top quarterbacks in CAA Football this season. The left-hander has completed 70.2 percent of his attempts for 1,068 yards and six touchdowns without an interception, and rushed for 87 yards and two touchdowns.
He was replaced in the Towson game by redshirt freshman Jack Schetelich, who accounted for all three Villanova touchdowns.
The Wildcats (3-2) will host Maine on Saturday.