Two-time Wimbledon champion Rafael Nadal found himself in an early hole Tuesday, down 4-0 in the opening set but roaring back to beat Brazilian left-hander Thomaz Bellucci 7-6 (0), 6-2, 6-3.
The Spaniard closed the match with an ace down the middle, his sixth of the day.
Nadal, coming off his record seventh French Open title, broke six times and had 35 winners and 18 errors. Having lost in last year's final to Novak Djokovic, he is bidding for a 12th Grand Slam title.
"I'm very happy to be back on the best court in the world and winning," Nadal said. "It's fantastic for me, but I have to improve a lot for the next round."
Play was later suspended for the day because of rain and poor light, leaving several matches unfinished. Three-time finalist Andy Roddick was leading Britain's Jamie Baker 7-6 (1), 4-2 on Court 1 when the covers came on. Tenth-seeded Sara Errani, runner-up at the French Open earlier this month, was holding match point in the second set when her match against American qualifier Coco Vandeweghe was halted.
Fourth-seeded Andy Murray of Britain swept to a 6-1, 6-1, 6-4 win in gloomy conditions on Centre Court over Nikolay Davydenko, a former No. 3-ranked player from Russia who has dropped to No. 47 and lost in the first round for the second year in a row. Murray, who has lost in the semifinals here the past three years, is still carrying the pressure of trying to become the first British player to win the men's title since Fred Perry in 1936.
Hewitt has slipped to 202nd in the rankings and needed a wild card for his 14th straight appearance at the All England Club. Tsonga was too powerful, racking up 61 winners to the Australian's 12. It was Hewitt's first opening-round loss here since 2003.
Hewitt was one of four Australians in the men's draw, and all bowed out in the first round. It marks the first time since 1938 that no Australian men have reached the second round at Wimbledon.
Playing his first match since having a medical procedure on his heart, 10th-seeded Mardy Fish of the United States served 24 aces and beat Ruben Ramirez-Hidalgo of Spain 7-6 (3), 7-5, 7-6 (1) to reach the second round.
The 30-year-old Fish, who reached the quarterfinals last year, hadn't played a competitive match in 2 1/2 months after having an accelerated heartbeat. He played attacking, serve-and-volley tennis and piled up 63 winners against Ramirez-Hidalgo - at 34, the oldest man in the field.
Jarkko Nieminen ousted 14th-seeded Feliciano Lopez of Spain, 7-6 (4), 3-6, 7-6 (5), 6-4.
In a men's match between two rising stars, 21-year-old Belgian wild card David Goffin -who reached the fourth round of the French Open and took a set off Federer - rallied from a set down against 19-year-old Bernard Tomic to beat the 20th-seeded Australian, 3-6, 6-3, 6-4, 6-4.