BALTIMORE -- Wade Miley allowed one run in seven innings, Mark Trumbo hit the first of Baltimore's four home runs off Eduardo Rodriguez and the Orioles beat the Boston Red Sox 7-5 on Thursday night.
Chris Davis and Adam Jones went deep for a second straight night and Jonathan Schoop capped the outburst with a three-run drive in the sixth that made it 7-1.
After taking two of three from the AL East-leading New York Yankees, the Orioles opened a four-game series against another division rival with a feel-good victory.
Miley (2-3) gave up five hits and a walk against the team he pitched for in 2015. Seeking his first win since April 14, the lefty did not allow a runner past first base after the second inning.
Rodriguez (4-2) surrendered seven runs in 5 2/3 innings, and the four homers tied a career high. The former Orioles farmhand came in with a four-game winning streak and a career 1.34 ERA in six starts at Camden Yards.
Jackie Bradley Jr. hit a three-run homer in the ninth inning and Christian Vazquez had two RBIs for the Red Sox, who lost for only the third time in 11 games.
When the Orioles visited Boston during the first week of May, a series of brushback pitches and harsh words in both clubhouses led the commissioner's office to intervene with instructions to end a feud that began in April with a spikes-high slide by Baltimore's Manny Machado into Boston second baseman Dustin Pedroia.
Before this game, Orioles manager Buck Showalter expected no residual ill will in a series between two teams within baseball's most competitive division.
"Your hands are full trying to stay with these guys as opposed to bringing in some unneeded drama," he said.
There was no drama after Jones led off the sixth with a home run and Schoop chased Rodriguez in the same inning.
Earlier, Trumbo hit a two-run drive and Davis made it 3-1 in the fourth with his team-high 12th home run, the first long ball allowed by Rodriguez to a left-handed batter since Brett Gardner of the Yankees last July.