Addison Russell hit a go-ahead solo home run in the ninth inning and the Chicago Cubs beat the Baltimore Orioles 9-8 after squandering an eight-run lead on Friday night.
Mark Trumbo tied the game 8-8 with a two-run homer off Koji Uehara (3-4) in the eighth. Russell responded when he hit a first-pitch, 96 mph fastball off Brad Brach (2-2) over the left field fence.
Wade Davis picked up his 17th save for Chicago.
Willson Contreras and Kyle Schwarber hit back-to-back homers in a four-run first inning for Chicago. Ben Zobrist also homered onto the flag court behind the right field scoreboard and Jason Heyward reached Eutaw Street with another towering shot.
Chicago improved to 3-6 in interleague play after going 15-5 against the AL last season.
Welington Castillo's ninth home run was a solo shot in the third for Baltimore, which left 10 runners on base.
Contreras provided a 3-0 lead with a homer into the Cubs' bullpen. Schwarber hammered Kevin Gausman's next pitch to almost the exact spot.
Zobrist and Heyward hit two-run homers in the second and third, respectively, to boost the margin to 8-0. Gausman tied a career-high by allowing eight runs and seven hits over three innings. He also gave up four home runs -- the most of his career.
Mark Trumbo, Trey Mancini and Joey Rickard had RBI singles in the fifth off reliever Justin Grimm to cut the lead to 8-6.