The 49ers’ running game received a boost on Saturday when the club activated JaMycal Hasty off the injured reserve list.
Hasty, who returns to action after sitting out three games with a high-ankle sprain, will be available on Sunday to face the Indianapolis Colts on what is expected to be a wet night at Levi’s Stadium.
The 49ers made a number of moves on the eve of their prime-time game against the Colts, including the elevation of quarterback Nate Sudfeld from the practice squad. Sudfeld will serve as Jimmy Garoppolo’s backup with rookie Trey Lance ruled out with a left knee sprain.
Veteran linebacker Mychal Kendricks was released less than a week after the 49ers signed him as a free agent.
The club promoted linebacker Tyrell Adams from the practice squad. Adams, 29, has 37 games of NFL experience with the Las Vegas Raiders and Houston Texans. He started 12 games for Houston last season.
Also, the 49ers elevated Tanner Hudson from the practice squad for the second consecutive game. Hudson will be the team's No. 3 tight end behind Ross Dwelley and Charlie Woerner. George Kittle is eligible to return off injured reserve Nov. 7 when the 49ers play the Arizona Cardinals at Levi's Stadium.
Hasty sustained his injury in the 49ers’ Week 2 victory over the Philadelphia Eagles. Hasty carried six times for 41 yards and a touchdown in the first two games. He also caught five passes for 36 yards.
Rookie running back Elijah Mitchell is expected to make his third start of the season. He leads the 49ers with 189 yards and a touchdown on 45 rushing attempts.
Trey Sermon, a third-round draft pick, is second on the team with 135 yards and a touchdown on 35 carries.