49ers-Bills predictions: Can SF beat first-place Buffalo?


The 49ers are getting healthy at the exact right time. With Deebo Samuel, Raheem Mostert and Richard Sherman back on the field last week, San Francisco upset the Los Angeles Rams. 

Brandon Aiyuk is back this week, and the 49ers are surprise favorites against the first-place Buffalo Bills. Can the Red and Gold take down Josh Allen and the Bills on "Monday Night Football" in Arizona? 

This will be the 49ers' first game in their new home. A win would keep them right in the playoff hunt and start a bizarre home-field advantage at State Farm Stadium. Here's how the experts see it playing out.

RELATED: 49ers CB Williams out vs. Bills; Moseley questionable


Line: 49ers -1

Odds provided by our partner, PointsBet.


Josh Schrock, NBC Sports Bay Area: Bills 24, 49ers 20

Nick Wagoner, ESPN: Bills 23, 49ers 20

Marcel Louis-Jacques: Bills 31, 49ers 18

Michael David Smith, Pro Football Talk: Bills 23, 49ers 10

Mike Florio, Pro Football Talk: 49ers 21, Bills 20

Gregg Rosenthal, NFL.com: Bills 27, 49ers 26


Download and subscribe to the 49ers Talk Podcast