Arik Armstead will miss his sixth straight game as the 49ers take on the Cardinals on Monday night in Mexico City while Arizona quarterback Kyler Murray is questionable.
Armstead on Saturday was ruled out for the Week 11 matchup at Estadio Azteca as the veteran defensive tackle continues to be hindered by plantar fasciitis in his right foot and a hairline fracture of his left fibula and there is no timetable for his return.
Fellow defensive tackle Samson Ebukam is listed as questionable for Monday's game as he deals with quadriceps and Achilles injuries. He didn't practice Thursday, though he was a limited practice participant Friday and Saturday after missing last week's win over the Los Angeles Chargers.
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The 49ers' defense fared well in Week 10 against Los Angeles without Armstead, Ebukam and Javon Kinlaw, who is on injured reserve, along the defensive line. Defensive end Nick Bosa tallied one sack in the win and is tied for second in the NFL with 9.5 total on the season.
Wide receiver Danny Gray (ankle) was limited in Friday's practice but returned Saturday as a full participant.
Meanwhile, Arizona is down one star after tight end Zach Ertz suffered a season-ending knee injury against the Los Angeles Rams in Week 10. Murray didn't play in that game due to a hamstring injury, and the quarterback was listed as questionable for Monday's game with San Francisco.
Along with Ertz, the Cardinals ruled out offensive tackle D.J. Humphries (back) and cornerback Byron Murphy (back) for Monday's game.
San Francisco 49ers
Wide receiver DeAndre Hopkins (hamstring) and guard Max Garcia (shoulder) are listed as questionable as well, and both were limited participants in Saturday's practice along with Murray.
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Murray's backup Colt McCoy, who was limited in Friday's practice with a knee injury, participated in full Saturday.
The 49ers and Cardinals will kick off at 5:15 PM PT on "Monday Night Football."