Jimmy Garoppolo might once again be without his favorite target when the 49ers host the Cardinals on Sunday.
San Francisco head coach Kyle Shanahan said Wednesday on a conference call with Cardinals reporters that tight end George Kittle will miss the game against Arizona.
Speaking about the 49ers' depth at tight end, Shanahan said "we're getting (Garrett) Celek back, but we won't have Kittle."
To no surprise, Shanahan's comments made waves around the internet as multiple reporters tweeted out his comments that Kittle has been ruled out.
However, a 49ers representative later clarified to NBC Sports Bay Area's Matt Maiocco that Shanahan misspoke on the conference call. The 49ers coach doesn't expect Kittle to play Sunday, but he won't rule him out at this time.
Kittle also sat out the 49ers' Week 10 overtime loss to the Seahawks with knee and ankle injuries. He originally was injured on San Francisco's first offensive play in the Week 9 win in Arizona, but still managed to catch six passes for 79 yards and a touchdown in that 28-25 victory. Kittle leads all 49ers' pass-catchers in receptions (46), receiving yards (541), yards after the catch (300) and first downs (28).
That's not the only bad news for Jimmy G, as he might be without his other top target as well. Emmanuel Sanders still is "day-to-day" with a rib injury and is considered a game-time decision for Sunday.
Sanders injured his ribs in the first half of the loss to Seattle. He led all 49ers' receivers with seven receptions for 112 yards and a score in the Week 9 win over the Cardinals, and has been a dependable safety valve ever since coming over from Denver at the trade deadline.
[RELATED: Sanders remains 'day to day' for 49ers with ribs still sore]
The 49ers are heavy favorites over the Cardinals, but missing Kittle and/or Sanders would make Garoppolo's job much tougher on Sunday.
When the Arizona Cardinals waived veteran linebacker Terrell Suggs on Friday, 49ers fans instantly wondered if the top team in the NFC would try to claim T-Sizzle.
NBC Sports Bay Area's Matt Maiocco believes Suggs would be a fit for the 49ers due to injuries to Ronald Blair, Damontre Moore and Dee Ford.
But you can lower your expectations, 49ers fans.
ESPN's Adam Schefter reported Saturday, citing league sources, that Suggs would "strongly consider not reporting if a team other than the Baltimore Ravens claims him."
Suggs spent the first 16 years of his NFL career in Baltimore, so it's understandable that the Ravens are the only team he wants to play for.
While it appears Suggs won't be donning a 49ers' uniform, it would still make sense for the 49ers to put in a waiver claim on the 37-year-old.
Assuming Suggs gets through the 30 teams ahead of the 49ers in the waiver order, the 49ers would be wise to try to block the linebacker from going to the Ravens.
After all, the 49ers and Ravens could meet up in Super Bowl LIV, and the last thing San Francisco wants to see is T-Sizzle coming after Jimmy Garoppolo.
[RELATED: Five 49ers to watch vs. Falcons]
And you never know. Maybe coach Kyle Shanahan and general manager John Lynch can convince Suggs to play for the 49ers.
Suggs' fate will be decided Monday when teams can put in a waiver claim on him. No matter what happens, the 49ers absolutely should claim him.
The 49ers (11-2) say they aren't taking the Atlanta Falcons (4-9) lightly this week, but Las Vegas might be.
San Francisco is a massive favorite ahead of Sunday's game at Levi's Stadium, favored by as many as 11 points. It marks the fourth time the 49ers have been double-digit favorites in a game this season, but the NFC West leaders have not covered the spread in any of those prior contests.
The fourth time could be the charm Sunday as Kyle Shanahan coaches against the Falcons for the first time. Shanahan was Atlanta's offensive coordinator from 2015 through 2016, including during the Falcons' 34-28 loss to the New England Patriots in Super Bowl LI. In other words, prepare yourself for plenty of "28-3" references during the game.
[RELATED: Why Shanahan isn't worried about Falcons being trap game]
Here's how Las Vegas and experts around the country see Sunday's game playing out.
Caesars: SF -11
Consensus: SF -11
Westgate: SF -10
Wynn: SF -11
Nick Wagoner, ESPN: 49ers 28, Falcons 21
Vaughn McClure: 49ers 30, Falcons 20
Mike Florio, Pro Football Talk: 49ers 28, Falcons 3
Michael David Smith, Pro Football Talk: 49ers 23, Falcons 10
Gregg Rosenthal, NFL Media: 49ers 40, Falcons 21