Jason Verrett was announced Sunday morning as a surprise inactive for the 49ers in their Week 15 game against the Dallas Cowboys.
The veteran cornerback is out due to a non-COVID-19 illness, the 49ers announced. Verrett has played at a high level during his 12 starts this season with two interceptions, six passes defensed and 44 tackles.
Meanwhile, cornerbacks K'Waun Williams and Emmanuel Moseley were both cleared to play and will be in uniform.
The 49ers' list of inactives also includes wide receiver Deebo Samule (hamstring), center Hroniss Grasu (knee) and linebacker Mark Nzeocha, who was activated off injured reserve on Saturday after being out for most of the season with a quadriceps injury.
Williams has appeared in just six games this season and has not suited up since sustaining a high ankle sprain on Nov. 5 against the Green Bay Packers. Dontae Johnson has filled in the past two games at nickelback.
Moseley, who has started eight of the nine games in which he appeared this season, will be back in action after missing two games due to a hamstring injury.
The 49ers will not have right guards Tom Compton or Colton McKivitz available for Sunday's game, so second-year player Justin Skule will receive his first start at a position other than left tackle. McKivitz went on the reserve/COVID-19 list, while Compton is on injured reserve after sustaining two concussions in a three-week span.
Tight end George Kittle, who practiced last week, remains on injured reserve and is not eligible to play against the Cowboys. Kittle has been out since sustaining a fractured bone in his foot on Nov. 1.
Quarterback Jimmy Garoppolo could be cleared for limited practice this week but appears unlikely to play again this season due to a high ankle sprain.
The Cowboys' list of inactive players includes star running back Ezekiel Elliott with a calf injury.