It's officially Trey Lance time for the 49ers, with veteran quarterback Jimmy Garoppolo officially inactive for Sunday's game against the Houston Texans.
The 49ers also will be without linebackers Dre Greenlaw and Azeez Al-Shaair, safety Talanoa Hufanga, defensive tackle Maurice Hurst, offensive lineman Colton McKivitz and tight end Tanner Hudson.
Third-string quarterback Nate Sudfeld will be Lance's backup.
The Texans will be without quarterback Deshaun Watson, defensive backs Cre'Von LeBlanc and Jimmy Moreland, and defensive linemen Chris Smith, Derek Rivers and Maliek Collins.
Kickoff is set for 1:05 p.m. PT at Levi's Stadium. The 49ers (8-7) can clinch an NFC wild-card playoff spot with a win over the Texans and a New Orleans Saints loss to the Carolina Panthers.