SANTA CLARA -- Running back Trey Sermon appears to be on pace to play Sunday night against the Green Bay Packers after sustaining a concussion at the end of his one and only NFL rushing attempt.
Sermon, whom the 49ers selected in the third round of the 2021 NFL Draft, could be the third different running back to start for the team in the first three games of the season.
He was fully cleared for game action on Friday after passing through the NFL's return to play protocol after sustaining a concussion on Sunday against the Philadelphia Eagles.
Fellow rookie running back Elijah Mitchell did not practice this week after sustaining a shoulder injury in the 49ers' 17-11 victory over the Philadelphia Eagles in Week 2. The 49ers listed Mitchell as doubtful. He is likely to miss the 49ers' home opener due to an injury to his AC joint.
The 49ers were already going to be missing three of their top running backs. Raheem Mostert is out for the season with a knee injury. Jeff Wilson Jr. is expected back in the middle of the season after undergoing offseason knee surgery. And JaMycal Hasty is expected to be out for an extended time with a high-ankle sprain of his left foot.
Hasty and defensive tackle Kevin Givens were both ruled out for Sunday's game ankle injuries. Both are likely to be heading to injured reserve, which requires an absence of a minimum of three weeks.
Defensive tackle Maurice Hurst, who was placed on injured reserve with a high-ankle sprain at the start of the season, could be returning off the list as early as next week to face the Arizona Cardinals.
The 49ers head into Sunday's game with the possibility of reserve running backs coming from among newly acquired Jacques Patrick, Trenton Cannon, along with Kerryon Johnson and Chris Thompson from the practice squad. The club is likely to elevate one of their practice-squad running backs for the game.
Cornerback Emmanuel Moseley, who missed the first two games of the season with a knee injury, appears to be on pace to play on Sunday against Aaron Rodgers and the Packers. Moseley took part in limited practices on Wednesday, Thursday and Friday.