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The 49ers suffered a big blow on Thursday when it was determined that No. 2 overall pick Nick Bosa will miss the next few weeks of practice due to a Grade 1 hamstring strain.

The injury originally occurred during Tuesday's organized team activity. The 49ers are concluding the first of four consecutive weeks of on-field work.

It's been a while since Bosa has been on a football field, as he sustained a bilateral core muscle injury in the third game of last year and underwent surgery, bringing his final season at Ohio State to an early end.

So with this latest injury, Bosa will miss valuable time learning the 49ers' defensive scheme.