After picking up two wins in New Jersey despite a plethora of injuries, the 49ers (2-1) are back in the friendly confines of Levi's Stadium as they host the Philadelphia Eagles (0-2-1) on NBC's "Sunday Night Football."
Coach Kyle Shanahan will have the services of two of his biggest offensive weapons in the primetime matchup. All-Pro tight end George Kittle returns to the lineup after missing the last two games with a sprained left knee, while dynamic wide receiver Deebo Samuel makes his 2020 debut after recovering from a Jones fracture in his foot.
Nick Mullens will make his second straight start at quarterback in place of Jimmy Garoppolo, who remains out with a high ankle sprain.
All four NFC West teams have a winning record entering Week 4, so the 49ers need a victory over the struggling Eagles to keep pace with the Seattle Seahawks, Arizona Cardinals and Los Angeles Rams.
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Here's how to watch 49ers-Eagles in Week 4:
When: Sunday, Oct. 4, at 8:20 p.m. ET/5:20 p.m. PT
TV channel: NBC
Live stream: NBCSports.com
After the afternoon NFL games end Sunday, go to NBC Sports Bay Area or the MyTeams app at 4 p.m. PT for "49ers Pregame Live," as Laura Britt, Jeff Garcia, Donte Whitner, Ian Williams, Matt Maiocco, Jennifer Lee Chan and Grant Liffmann preview the "Sunday Night Football" matchup against the Eagles. Then, after the game, come back for "49ers Postgame Live," with highlights, analysis, interviews and more.