Week 1: Monday, Sept. 12, vs. Los Angeles, 7:20 p.m. (ESPN)
The 49ers will renew their NorCal-SoCal rivalry that ran from 1950 to 1994 with an appearance at Levi’s Stadium from Jeff Fisher’s Rams and their No. 1 overall draft pick. But will Jared Goff or Carson Wentz be watching from the sideline? It’s the 49ers’ only appearance on Monday Night Football this season.
Week 2: Sunday, Sept. 18, at Carolina, 10 a.m. (FOX)
After the Super Bowl losers open on the road against the Super Bowl-winning Denver Broncos, the 49ers get the honor of being the opponent for the Panthers’ home opener. For the second consecutive year, the 49ers open on a late Monday night, then travel to the East Coast. Last year, it didn't work out so well for the 49ers against the Pittsburgh Steelers.
Week 3: Sunday, Sept. 25, at Seattle, 1:05 p.m. (FOX)
It’s a tough back-to-back for Chip Kelly to close out his opening month of the regular season.
Stay in the game with the latest updates on your beloved Bay Area and California sports teams! Sign up here for our All Access Daily newsletter.
Week 4: Sunday, Oct. 2, vs. Dallas, 1:25 p.m. (FOX)
This is a matchup of last year’s fourth-place teams from their respective divisions. The Cowboys could be in line to make a leap . . . if Tony Romo remains healthy.
Week 5: Thursday, Oct. 6, vs. Arizona, 5:25 p.m. (CBS/NFL Network/Twitter)
The 49ers do not have to travel on their only Thursday game of the season with a home date against the defending division champion Cardinals.
Week 6: Sunday, Oct. 16, at Buffalo, 10 a.m. (FOX)
Bills offensive coordinator Greg Roman, whom the 49ers let go in the messy parting with Jim Harbaugh, was immediately hired when Rex Ryan got this job. The 49ers do not have to face the Bills’ power-running game in December weather.
Week 7: Sunday, Oct, 23, vs. Tampa Bay, 1:05 p.m. (FOX)
The 49ers liked what they heard during their interview with Dirk Koetter, but he was never offered the job. After all, why would he have left a situation with a franchise-type quarterback for the 49ers’ unsettled situation?
San Francisco 49ers
Week 8: Bye
Week 9: Sunday, Nov. 6, vs. New Orleans, 1:05 p.m. (FOX)
After some initial thought the 49ers could make a run at Sean Payton, the Saints locked kept him off the market. Payton and Drew Brees remain together and face the 49ers, who are coming off the bye week.
Week 10: Sunday, Nov. 13, at Arizona, 1:25 p.m. (FOX)
As long as the 49ers do not throw two pick-sixes within the first six minutes of the game, they should be in better shape than a year ago when they visited the desert.
Week 11: Sunday, Nov. 20, vs. New England, 1:25 p.m. (CBS)
One final reminder at how the 49ers selected quarterbacks Giovanni Carmazzi and Tim Rattay in the 2000 draft and let Tom Brady slide.
Week 12: Sunday, Nov. 27, at Miami, 10 a.m. (FOX)
Adam Gase, whom the 49ers passed over in favor of Jim Tomsula a year ago, gets his chance to exact some revenge on general manager Trent Baalke.
Week 13: Sunday Dec. 4, at Chicago, 10 a.m. (FOX)
The highlight of the 49ers’ season – a “very fun win,” in Jed York’s words – came at Soldier Field on Blaine Gabbert’s 71-yard touchdown pass to Torrey Smith against Vic Fangio’s defense. Who will be throwing the passes this time around?
Week 14: Sunday, Dec. 11, vs. N.Y. Jets, 1:05 p.m. (CBS)
The schedule-maker was kind to the 49ers. Not only are the Jets traveling across the country, they’re doing it on a short week after a Monday night game against the Indianapolis Colts.
Week 15: Sunday, Dec. 18, at Atlanta, 1:05 p.m. (FOX)
The 49ers got the better of the Falcons last season in Santa Clara in Dan Quinn’s first season. Now, Quinn gets the 49ers on his home turf.
Week 16: Saturday, Dec. 24, at Los Angeles, 1:25 p.m. (FOX)
While most of the rest of the NFL is playing on Christmas Day (1:25 p.m.), the 49ers have the chance to play the game and be back in plenty of time to open presents.
Week 17: Sunday, Jan. 1, vs. Seattle, 1:25 p.m. (FOX)
The 49ers ring into the New Year against an old friend. The 49ers have victories at Levi’s Stadium against the Rams and Cardinals. But they’re 0-2 on their new home field against the Seahawks.