SANTA CLARA -- The 49ers do not expect linebacker Reuben Foster or safety Eric Reid to be available for Sunday’s game against the Indianapolis Colts.

Foster sustained a high right ankle sprain on the 11th play of the 49ers’ season opener on Sept. 10 against the Carolina Panthers. He was originally expected to be out four to six weeks. Reid went down with a partially torn posterior cruciate ligament in his left knee in Week 2. Neither player required surgery to repair their injuries.

“We’ll see how his rehab goes these next three days,” 49ers coach Kyle Shanahan said of Foster. “I'd be surprised if he got back this week. I'm not totally ruling him out, but it would surprise me. Being optimistic about it, but if we don't get him back this week, hopefully we’ll get him out there next week.”

Reid is also not likely to play against the Colts, Shanahan said.

“He's coming along,” Shanahan said. “I think he's similar to Reuben. I'd be surprised if he was out there this week. A little more optimistic for next week. But, still, no guarantees.”

Wide receiver Marquise Goodwin is in the NFL’s concussion protocol after sustaining his third concussion since August of 2016. Goodwin sustained a head and eye injury in the first quarter and was later diagnosed with a concussion.

Running back Carlos Hyde is expected to be limited in practice again this week due to a hip condition. He sustained the original injury in Week 3 against the Los Angeles Rams.


“I know he battled through that game,” Shanahan said. “I know he wasn't feeling great, but he played well. Appreciate him being out there and playing hard, and I know I didn't get to talk to him personally. I'm sure he's extremely sore from it, but we'll see Wednesday when he comes back in.”

Linebacker Dekoda Watson (groin) and rookie safety Adrian Colbert (hamstring) are not expected to be available for Sunday’s game.