The San Francisco 49ers enter Week 2 of the 2021 NFL Season undefeated after narrowly defeating the Detroit Lions 41-33 last Sunday.
Both Jimmy Garoppolo and Trey Lance threw touchdown passes, while Deebo Samuel had a career day, registering a career-high 189 receiving yards on nine catches and a touchdown.
Garoppolo had an impressively efficient performance, completing 17 of 25 passes for 314 yards and one touchdown.
But perhaps the biggest surprise was the emergence of rookie running back Elijah Mitchell. After Raheem Mostert left the season opener with a knee injury, Mitchell made the most of his opportunity, rushing for 104 yards and his one touchdown in his NFL debut. Mitchell was drafted in the fourth round after second-round pick Trey Sermon, but it appears he could be the 49ers’ workhorse heading into Week 2. Mostert was initially expected to miss half the season after suffering chipped knee cartilage but opted to have season-ending arthroscopic knee surgery.
The 49ers will attempt to win back-to-back games on the road when they head to Lincoln Financial Field to face the Philadelphia Eagles. The Eagles also were victorious in Week 1, defeating the Atlanta Falcons 32-6. The first game of the Nick Sirianni era couldn’t have gone much better as Jalen Hurts threw for 264 yards and three touchdowns in the rout. Philadelphia’s No. 10 overall pick DeVonta Smith also had a strong start to his NFL career, catching six passes for 71 receiving yards and the first touchdown of the game.
In order for Kyle Shanahan and the 49ers to advance to 2-0, they must find a way to stop Hurts and the Eagles’ passing attack. That might prove to be difficult without Jason Verrett, who was placed on season-ending IR after tearing his ACL on Sunday. The 49ers still have Emmanuel Moseley, who’s dealing with a knee injury of his own.
The team will have to rely on veteran Josh Norman -- who signed with the 49ers last Monday -- fifth-round pick Deommodore Lenoir, fellow rookie Ambry Thomas and Dontae Johnson, who was called up from the practice squad last Saturday.
If the 49ers’ secondary can get some help from Nick Bosa, Arik Armstead and the defensive line, putting pressure on Hurts to make him rush throws, the secondary should be able to take advantage despite their lack of experience.
Here is everything you need to know for the 49ers’ Week 2 contest and how to watch the game:
What time do the 49ers play in Week 2?
Kickoff between the 49ers and Eagles is set for 10 a.m. PT on Sunday, Sept. 19, at Lincoln Financial Field in Philadelphia.
What TV channel is the 49ers game on?
49ers-Eagles will air on FOX. Adam Amin (play-by-play), Mark Schlereth (analysis) and Shannon Spake (sideline reporter) will be on the call.
The 49ers First Look show will begin at 8 a.m. PT, with 49ers Pregame Live following shortly after at 9 a.m. PT. Both shows will air on NBC Sports Bay Area and are available to stream here and in the MyTeams app.
The crew returns for 49ers Postgame Live on NBC Sports Bay Area right after the game to break down all the action in Week 2. Watch the show live here and in the MyTeams app.
How to stream 49ers vs. Eagles live online
Free streaming option: FuboTV (free trial)
How to listen to 49ers vs. Eagles on the radio
Are the 49ers favorites against the Eagles?
The 49ers are a three-point favorite against the Eagles in Week 2, according to our partner, PointsBet. Philadelphia narrowly defeated the 49ers in Week 4 of the 2020 season by a score of 25-20 on Sunday Night Football. Nick Mullens and C.J. Beathard combined for 338 yards with Mullens nabbing the lone passing touchdown for the 49ers. Brandon Aiyuk scored the first rushing touchdown of his career, leaping over Eagles’ safety Marcus Epps in a play that went viral.
Check out the full betting preview for the game here.
Editor's note: All odds are provided by our partner, PointsBet. PointsBet is our Official Sports Betting Partner and we may receive compensation if you place a bet on PointsBet for the first time after clicking our links.