Fourth quarter, 13:47, Chiefs 38-24: Harrison Butker just squeaks in a 37-yard field goal, as the 49ers’ defense holds and keeps it a two-score game.
End of the third quarter, Chiefs 35-24: Kansas City ends the quarter with the ball at the San Francisco 23, with Patrick Mahomes finding success against a makeshift 49ers secondary after injuries ravaged the group in game.
Third quarter, 2:43, Chiefs 35-24: Alfred Morris powers his way into the end zone for a 3-yard touchdown run, George Kittle scores on a two-point conversion shovel pass – and it has become very interesting at Arrowhead Stadium.
Jimmy Garoppolo willed the 49ers to eight points on that drive, with a clutch third-and-6 throw to Kittle and a second-and-10 laser to Matt Breida at crucial junctures.
Third quarter, 7:58, Chiefs 35-16: Halftime appears to have cooled off the Chiefs’ offense, which just went three-and-out.
The 49ers have the ball at their own 23 after a costly block-in-the-back penalty on the punt return. If they’re going to get back in this game, now is the time.
Defensive players also need to stop getting hurt.
Third quarter, 9:04, Chiefs 35-16: Marquise Goodwin is wide open, and Jimmy Garoppolo doesn’t miss, hitting him for an 11-yard touchdown pass. Robbie Gould surprisingly doinks the extra-point attempt, however.
Matt Breida injected life into the 49ers’ offense with his speed and elusiveness, busting two 21-yard runs on sweeps to the left and then the right. Garoppolo missed a wide-open Pierre Garcon on the drive, but he didn’t make the same mistake to Goodwin.
Third quarter, 11:43, Chiefs 35-10: The 49ers’ defense prevents a Chiefs touchdown drive for the first time all game, although Demetrius Harris bails them out by dropping a third-down pass.
Niners ball at their 13, and quite the hole to dig out of right now. But there’s good news for them at running back …
Third quarter, 15:00, Chiefs 35-10: Kansas City receives the opening kickoff, which sails into the end zone for a touchdown. Suffice to say that San Francisco’s defense needs to hold here.
And while Richard Sherman tries to shake off a calf injury, the 49ers make adjustments at cornerback.
Halftime, Chiefs 35-10: Robbie Gould drills a 39-yard field goal, and the 49ers’ first-half nightmare mercifully is over.
Not much else to say, although Matt Maiocco, our 49ers insider, probably did it best.
Also, here’s the latest on 49ers running back Matt Breida and cornerback Richard Sherman, who have left the game with injuries.
Second quarter, 0:34, Chiefs 35-7: Sammy Watkins jets into the end zone for a 12-yard touchdown reception, and Kansas City is firmly in control, with Patrick Mahomes making history.
Chiefs tight end Travis Kelce kept the drive going with an incredible one-handed grab to convert a third-and-9 and move his team to midfield.
Second quarter, 2:00, Chiefs 28-7: Nothing doing for the 49ers’ offense. Again.
Kansas City has the ball at its 32 and could turn this game into a laugher before halftime.
Second quarter, 3:10, Chiefs 28-7: And 49ers running back Matt Breida is walking off the field after it appeared he hyperextended his right knee. Not. Good.
Second quarter, 3:37, Chiefs 28-7: Kansas City’s offense won’t let up.
Patrick Mahomes marches the Chiefs 72 yards in eight plays in 3:35 and hits wide-open Demetrius Harris on a 13-yard touchdown pass.
Mahomes is 11-of-18 passing for 179 yards and two TDs.
The 49ers, meanwhile, need an answer -- and fast.
Second quarter, 7:12, Chiefs 21-7: The 49ers go three-and-out. Not exactly the way to respond.
Second quarter, 9:04, Chiefs 21-7: Patrick Mahomes just showed why he’s getting all the hype.
Facing third-and-goal at the 49ers' 4, Mahomes scrambles to his left, then back to his right, buying time as San Francisco defenders chase him. He then fires a dart to Chris Conley in the back corner of the end zone for another Kansas City touchdown.
This after Mahomes connected with deep balls to Travis Kelce (25 yards) and Tyreek Hill (42 yards) …
Second quarter, 12:01, Chiefs 14-7: Jimmy Garoppolo just faked the entire Chiefs defense out of their pants.
Garoppolo fakes a handoff to Alfred Morris -- who had converted a fourth-and-1 run on the previous play -- and Kansas City bites. Hard.
Jimmy G spots Kyle Juszczyk wide open down the right sideline for a 35-yard touchdown pass, and it’s a game again.
Also, cornerback Tarvarius Moore is back.
End of the first quarter, Chiefs 14-0: The 49ers will face first-and-25 when play resumes, as a Mike Person illegal block penalty pushes them back into their own territory.
San Francisco has just 47 yards and four first downs – and that won’t keep 49ers fans from pleading for Le’Veon Bell, whom the Steelers could trade, if an ESPN report proves true.
First quarter, 2:20, Chiefs 14-0: A controversial calls goes the Chiefs’ way, and they take advantage with another Kareem Hunt 1-yard touchdown run.
On the previous play, 49ers cornerback K’Waun Williams was called for pass interference in the end zone, although Patrick Mahomes’ third-and-16 pass sailed way over the receiver’s head. The 49ers, obviously, weren’t happy about the call.
The 49ers also might have an injury concern in their secondary, which already is having trouble with Mahomes and the Chiefs’ offense.
First quarter, 5:46, Chiefs 7-0: The 49ers’ offense stalls after a 26-yard Matt Breida run and a 13-yard pass from Jimmy Garoppolo to Marquise Goodwin puts San Francisco at the Kansas City 36.
Three plays later, the 49ers have to punt, and the Chiefs take the ball at their 16.
First quarter, 8:24, Chiefs 7-0: Chiefs coach Andy Reid rolls the dice on fourth-and-1 at the 49ers’ 19, running a Patrick Mahomes option play instead of attempting a field goal. Reid’s gamble works, as Mahomes plunges 2 yards for a first down.
Two plays later, Kareem Hunt strolls into the end zone for a 1-yard touchdown.
The 49ers’ defense struggled to stop screen passes on the drive, yielding 14 yards on a third-and-15 pass to Spencer Ware just before Mahomes’ fourth-down run and allowing 16 yards to Anthony Sherman to put the Chiefs at the 1.
First quarter, 13:19, 0-0: The 49ers receive the opening kickoff but go three-and-out and have to punt. The Chiefs' first drive starts at their own 43-yard line against these 49ers defensive sets.
9:37 a.m.: Matt Maiocco bumped into two 49ers fans who wrote letters to Dwight Clark before the San Francisco legend died after his battle with ALS.
9:13 a.m.: Jimmy Garoppolo and C.J. Beathard found an interesting place to play catch before the game.
8:52 a.m.: Matt Maiocco is on the field at Arrowhead Stadium, and has the latest on the 49ers' starting linebackers against the Chiefs.
8:41 a.m.: After missing the first two games of the season because of suspension, linebacker Reuben Foster will be back in action for the 49ers.
8:30 a.m.: After going through pregame warmups, 49ers wide receiver Marquise Goodwin officially is active. Safety Jaquiski Tartt and guard Joshua Garnett highlight the inactive players for the 49ers.
8:13 a.m.: 49ers wide receiver Marquise Goodwin, who has been listed as questionable all week with a quadriceps injury, is on the field in Kansas City and warming up pretty vigorously. He was seen making lots of quick cuts and running at full speed. According to Matt Maiocco, Goodwin looks good.
8:04 a.m.: As we wait for 49ers and Chiefs inactives to be announced, Matt Maiocco is on the field at Arrowhead and is providing the First Look on Facebook Live right here!
7:45 a.m.: The 49ers face a stiff test in Kansas City on Sunday. No one is hotter than Chiefs quarterback Patrick Mahomes, who has thrown 10 touchdown passes through two games, and 49ers cornerback Ahkello Witherspoon certainly will be targeted by the second-year pro. It will be up to Witherspoon to respond while coming off a shaky game against the Lions.
Linebacker Reuben Foster is back from a two-game suspension, and the dynamic playmaker should give the 49ers' defense a big boost. Foster is one of four players Matt Maiocco wants you to watch in the game at Arrowhead Stadium.
Running back Matt Breida had a breakout game last week, rumbling for 138 yards, and that briefly put the second-year pro atop the NFL's rushing leaders. Browns running back Carlos Hyde moved ahead of Breida on Thursday night. Can Breida reclaim the top spot?
49ers quarterback Jimmy Garoppolo is looking to pick up his second consecutive win after suffering his first career loss in the season opener.
This Sunday, be sure to watch 49ers Pregame Live at 9 a.m. on NBC Sports Bay Area and 49ers Postgame Live immediately after the game on NBC Sports Bay Area Plus and live streaming on the NBC Sports app. Greg Papa, Donte Whitner, Jeff Garcia, Matt Maiocco and Laura Britt will have everything you need to know from the 49ers’ home opener.