Before the injuries started to pile up for the 49ers, their prime time game against the Packers was supposed to be must-see TV. But with quarterback Jimmy Garoppolo and running back Jerick McKinnon out for the year, the 49ers (1-4) take on Green Bay (2-2-1) as 9-point underdogs.
Kyle Shanahan needs a big performance from his defense, and as Matt Maiocco writes, defense end DeForest Buckner is one of four 49ers players to watch against the Packers.
Here's how writers covering the game and others from around the country see the game playing out:
Nick Wagoner, ESPN.com: Packers 31, 49ers 17
Rob Demovsky, ESPN.com: Packers 37, 49ers 17
Elliot Harrison, NFL.com: Packers 30, 49ers 14
Pete Prisco, CBS Sports: Packers 31, 49ers 13
John Gworek, Athlon Sports: Packers 30, 49ers 16
Matt Barrows, The Athletic: Packers 24, 49ers 20
David Lombardi, The Athletic: Packers 26, 49ers 20
Tim Kawakami, The Athletic: Packers 30, 49ers 24
Marcus Thompson, The Athletic: Packers 34, 49ers 17
Tom Silverstein, Journal Sentinel: Packers 37, 49ers 17