Quarterback Trey Lance now begins his road back to the playing field.
Lance underwent season-ending surgery on Monday morning to repair a fractured right ankle and ligament damage at Stanford Hospital, the team announced in a statement.
The 49ers described the areas repaired as a fibula fracture (non-weight-bearing bone of the lower leg) and "ligament disruption."
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"Lance will start the rehab process, and head team physician Dr. Tim McAdams is confident that he will recover completely in time for a full return in the 2023 season," the 49ers said in a statement.
Lance sustained the devastating injury in the first quarter of the 49ers' 27-7 victory over the Seattle Seahawks on Sunday.
Lance's right leg awkwardly got stuck underneath 345-pound Seattle defensive tackle Brian Mone and linebacker Cody Barton at the end of a running play that gained 2 yards.
San Francisco 49ers
Lance had three rushing attempts for 13 yards in the first 12 1/2 minutes of the game.
Veteran Jimmy Garoppolo took over for Lance on Sunday and played efficiently as the 49ers evened their record at 1-1 for the season.
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Garoppolo completed 13 of 21 pass attempts for 154 yards with one touchdown and no interceptions. He also had a 1-yard touchdown run.
Now, the 49ers move forward with Garoppolo as the starting quarterback and rookie Brock Purdy as the backup. The 49ers return to action Sunday night against Russell Wilson and the Denver Broncos.