After years of making life tough on 49ers quarterbacks, Richard Sherman has the shoe on the other foot nowadays, and he made perhaps his most important play yet in a San Francisco uniform during the third quarter of the 49ers' Week 1 matchup with the Buccaneers.

Shortly after Jimmy Garoppolo completed his first passing touchdown since tearing his ACL in Week 3 of last year, Sherman further increased San Francisco's lead to 20-7 on Sunday with a pick-six of Tampa Bay quarterback Jameis Winston.

Ironically, it was a near-mirror image of a first-half Garoppolo interception, which the Bucs also returned for a touchdown.

The interception marked Sherman's first since coming over to the 49ers from the Seahawks. It also was San Francisco's second interception of the game after Mark Nzeocha tallied one in the first half.

The 49ers set an NFL record for the fewest interceptions in a season with just two last year, so they've already matched that total before the conclusion of their first game.