OAKLAND -- Stephen Piscotty hit a tiebreaking, two-run single with two outs in the sixth inning and the Oakland Athletics held on to beat the Los Angeles Angels 6-4 on Saturday.
Sean Manaea (6-6) pitched four-hit ball and allowed three runs over six innings. The left-hander retired the first 12 batters, stumbled through a shaky fifth, then recovered for his first win in more than a month.
Chris Young, a late replacement after Angels left fielder Justin Upton was scratched from the starting lineup 40 minutes before first pitch, hit a three-run home run for Los Angeles.
The A's had lost six straight and 12 of 13 to AL West teams before rallying to beat the Angels for only the third time this season.
Semien homered leading off the sixth to chase Los Angeles starter John Lamb. Reliever Noe Ramirez (2-3) hit Pinder with a pitch, retired Jed Lowrie on a fly out, then walked Khris Davis before hitting Matt Olson to load the bases.
Ramirez struck out pinch-hitter Dustin Fowler but Lucroy walked to force in the tying. Piscotty then lined a 1-1 pitch to center, scoring Davis and Olson.
Lowrie added an RBI single in the seventh.
Yusmeiro Petit and Lou Trivino retired three players apiece. A's closer Blake Treinen gave up a two-out RBI single to pinch-hitter Jose Fernandez in the ninth but got Luis Valbuena to ground out for his 15th save.
Young homered in the fifth following back-to-back singles by Albert Pujols and Martin Maldonado. It was Young's second home run in four days after hitting two through his first 42 games.
Lamb pitched into the sixth inning and allowed a pair of solo home runs in his first start since July 16, 2016. He struck out five and walked one. The 27-year-old left-hander missed 50 games last season after testing positive for drugs while in the minors.
Angels: Upton was a late scratch due to lower back stiffness.
Athletics: Third baseman Matt Chapman was placed on the 10-day disabled list with a bruised right hand and will meet with hand specialist Dr. Steven Shin on Monday in Los Angeles. Chapman took infield practice before the game but did not throw. . LHP Brett Anderson threw 30 pitches in the bullpen.