Washington (18-13) entered the Pac-12 tournament hoping boost its slim NCAA Tournament chances. The eighth-seeded Huskies got off to a strong start against Stanford, building a 17-point lead in the game's first six minutes.
Washington continued to pour it on after that opening burst, shooting 50 percent to earn a spot in Thursday's second round against top-seeded Oregon.
Andrew Andrews had 14 points, nine rebounds and nine assists for the Huskies.
Stanford (15-15) stumbled through the regular season and fell flat in its lone postseason game, potentially putting coach Johnny Dawkins' job in jeopardy.
Dorian Pickens had 17 points to lead the Cardinal, who were 3 of 21 (14 percent) from 3-point range.
The Huskies won the lone meeting during the regular season 64-53 behind Murray's 25-point night.
They turned the rematch in a rout quickly, scoring the game's first 10 points while racing out to a 20-3 lead.
Stanford had three of its first five shots blocked and had five free throws until Michael Humphrey hit a layup for the Cardinal's first field goal 8:43 into the game.
Washington didn't let up from there.
The Huskies kept hounding the Cardinal into missed shots and even went to a press late in the half with the lead close to 20.
Washington made 18 of 34 shots, including 7 of 13 from 3-point range. Murray had 13 points by halftime, Chriss 12 and the Huskies led 50-22.
The Cardinal went 7 for 24 from the field, missing all six of their 3-point attempts, and had 11 turnovers that led to 15 points for the Huskies.
Stanford started making a few more shots in the second half and the Huskies didn't have it quite as easy, but the game was too far out of reach to matter.
Stanford: The Cardinal made 16 of 36 shots in the second half. ... Freshman C Josh Sharma missed his only shot and fouled out in 11 minutes.
Washington: Malik Dime blocked three shots to tie Robert Upshaw's single-season record of 85 set in 2014-15. ... The Huskies had a 25-12 advantage in second-chance points.
Stanford's season is likely over.
Washington will face No. 1 seed Oregon in the second round on Thursday.