Jason Witten's first touchdown as a Raider also marked a major milestone for Derek Carr.
The quarterback matched Raiders Hall of Famer Ken Stabler for the most passing touchdowns in franchise history with his 150th in the NFL.
Carr would later take over the all-time Raiders record with a fourth-quarter touchdown pass to Nelson Agholor.
Stabler reached the mark in 10 seasons with the Silver and Black, while it took Carr just seven to do the same.
Witten joined the Raiders in free agency after 16 seasons with the Dallas Cowboys, and is a solid veteran backup for Carr's favorite target in Darren Waller.
Las Vegas went on to lose 30-23 to Buffalo to fall to 2-2 this season.