Celtics vs. Pistons odds: Best NBA picks with Jayson Tatum out due to injury

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The Boston Celtics will see what life is like without their second-leading scorer Wednesday night.

Jayson Tatum has been ruled out of the Celtics' matchup with the Detroit Pistons due to tendinitis after pouring in 62 points over his last two games.

It's the first game Tatum will miss this season, but the good news is that Boston has rebounded from a three-game losing streak to win it last two contests by a combined 47 points.

Can the Celtics win their third straight game Wednesday night, or will Tatum's absence open the door for a Pistons upset?

Below are our moneyline, point spread and point total predictions for Celtics-Pistons, as well as two NBA locks against the spread.

(All odds provided by WestGate Superbook.)

LIVE stream the Celtics all season and get the latest news and analysis on all of your teams from NBC Sports Boston by downloading the My Teams App.

Detroit Pistons at Boston Celtics, 7 p.m. ET

Moneyline: The Pistons' last two losses (vs. Chicago, vs. New Orleans) were to teams the Celtics (-500) just handled with ease. Even if Boston plays down to its competition, Detroit is too bad of a team to beat the Celtics.

Point Spread: I actually think Tatum's absence will help Boston play with a little urgency. Gordon Hayward and Jaylen Brown make the most of their increased touches and help the Celtics (-9) cruise to a double-digit victory.

Point Total: The point total has gone under in six of Boston's last seven games against Eastern Conference opponents, and I don't trust the Pistons' offense enough to push this over the 218 point total. I'll take the UNDER.

Darren's record picking the Celtics' moneyline, point spread and point total: 55-28-1 (65.5% success rate)

NBA Locks of the Night

Brooklyn Nets at Philadelphia 76ers (-7): Is there a more Jekyll-and-Hyde team than the Sixers? Philly has lost its last six road games but is 18-2 at home. The Nets haven't won a road game since Dec. 17, so I'll back Dr. Jekyll.

Toronto Raptors at Oklahoma City Thunder (-1.5): The Thunder are 8-2 in their last 10 games, a run that includes a win in Toronto over the limping Raptors. I like them taking care of business at home.

Darren's record picking NBA locks against the spread: 28-27-1 (50% success rate)

Don't miss NBC Sports Boston's coverage of Pistons-Celtics, which tips off Wednesday at 6 p.m. with Celtics Pregame Live, and then Mike and Scal have the call at 7 p.m. You can also stream the game on the MyTeams App.

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