1. Christian McCaffrey, Carolina Panthers (vs. LV)
The consensus No. 1 overall pick in this year's fantasy drafts is likely to be the No. 1 option among RBs most weeks this season as long as he's healthy. The favorable matchup vs. the Raiders makes Week 1 even more exciting for McCaffrey owners.
2. Ezekiel Elliott, Dallas Cowboys (at LAR)
You can always count on 'Zeke to get a heavy workload and make the most of it. He's as safe of a play as it gets this week in L.A.
3. Dalvin Cook, Minnesota Vikings (vs. GB)
Cook proved last year what he's truly capable of when healthy. He finished as the No. 5 RB despite missing two games. Look for him to remind the world what he can do in Week 1 vs. the Packers.
4. Josh Jacobs, Las Vegas Raiders (at CAR)
Jacobs gets a nice matchup vs. Carolina in Week 1 of his sophomore season. The 22-year-old was outstanding as a rookie and should take another step forward if he can get more involved in the passing game.
5. Saquon Barkley, New York Giants (vs. PIT)
Barkley was the No. 2 pick in most fantasy drafts, so it may seem odd to find him down at fifth on this list. The matchup vs. a tough Steelers defense makes Barkley's outlook a bit murky, but he should still get enough touches to produce a solid fantasy day.
6. Alvin Kamara, New Orleans Saints (vs. TB)
Kamara remains one of the most dynamic dual-threat RBs in the game league, so you're starting him no matter what. Just keep in mind that Tampa has a rock-solid run defense and could make it difficult on the 25-year-old.
7. Austin Ekeler, Los Angeles Chargers (at CIN)
Even with Philip Rivers gone, I'm high on Ekeler this season. He burst on the scene as a dual-threat RB in 2019 and should get the bulk of the touches in the Chargers offense in 2020. Cincinnati is a nice matchup to kick things off.
8. Derrick Henry, Tennessee Titans (at DEN)
Henry is as close as one can get to a lock for double-digit fantasy points. Denver isn't the best matchup for the 2019 rushing leader, but he's an automatic start regardless.
9. Joe Mixon, Cincinnati Bengals (vs. LAC)
Mixon has rushed for more than 1,000 yards and both of his first two NFL seasons and I expect him to take another step forward with Joe Burrow now at QB for the Bengals. Expect a heavy workload for Mixon in Week 1 as Burrow gets comfortable.
10. Aaron Jones, Green Bay Packers (at MIN)
It remains to be seen how the addition of A.J. Dillon will impact Aaron Jones' fantasy value, if at all. For now, I like him to put up solid numbers in Week 1 vs. the Vikings.
11. Clyde Edwards-Helaire, Kansas City Chiefs (vs. HOU)
It's impossible to predict how a rookie RB will fare in his NFL debut. That being said, the Chiefs seem to turn everyone into a fantasy star, and I can't see why Edwards-Helaire would be any different.
12. Miles Sanders, Philadelphia Eagles (at WAS)
It's a great Week 1 matchup for Sanders, but it look like Philly may take it easy on his workload to begin the 2020 campaign as he recovers from a hamstring injury.
UPDATE (Saturday, 4 p.m.): Sanders is out for Sunday's game vs. Washington. Boston Scott is slated to be the lead back for Philly and is worth a flex play.
13. James Conner, Pittsburgh Steelers (at NYG)
It's all about health for Conner, who was unable to stay on the field in 2019. Assuming that changes in 2020, he should be considered a top-10 fantasy RB and a reliable start for Week 1 vs. the Giants.
14. Nick Chubb, Cleveland Browns (at BAL)
Don't sweat the presence of Kareem Hunt. Nick Chubb is still going to be a beast. The Ravens are a difficult matchup for Chubb in Week 1, but that didn't matter last year when he went off against his division rival. Start him with confidence.
15. Chris Carson, Seattle Seahawks (at ATL)
Carson, who has dealt with a hip injury, says he's "100 percent" heading into this season. We'll just have to wait and see about that, but until we see otherwise he's a must-start in pretty much all fantasy formats.
16. Kenyan Drake, Arizona Cardinals (at SF)
Drake won a lot of people their fantasy leagues last season after joining the Cardinals. While I expect him to be a solid option in 2020, I don't expect him to be the elite RB we saw a year ago. Manage your expectations with Drake, especially in Week 1 vs. a stifling 49ers defense.
17. Mark Ingram II, Baltimore Ravens (vs. CLE)
Ingram's expectations have been lowered following the addition of rookie RB J.K. Dobbins, but I don't think that's fair. He finished as the No. 8 fantasy RB last season despite his electric QB Lamar Jackson stealing a lot of the goal-line carries. Sure, Ingram is getting up there an age, but don't sell him short until we actually start to see regression.
18. David Johnson, Houston Texans (at KC)
Johnson was a disaster for fantasy owners last season. That being said, the Texans are a nice landing spot for the 28-year-old. Bill O'Brien gives his backs plenty of work and that should only increase with DeAndre Hopkins out of town. Expect a heavy dose of Johnson on the ground and through the air in this Week 1 matchup vs. the Chiefs.
19. Todd Gurley, Atlanta Falcons (vs. SEA)
Gurley should get plenty of work with his new offense, not to mention Atlanta's offensive line is far superior to L.A.'s. I expect a solid Falcons debut for the former Rams star.
20. Melvin Gordon, Denver Broncos (vs. TEN)
We have to wait and see how the RB situation shakes out in Denver with Phillip Lindsay likely to get plenty of carries as well, but Gordon should get the bulk of the work. He's a solid RB2 most weeks as long as he's healthy.
21. Le'Veon Bell, New York Jets (at BUF)
The Bills won't be the best matchup for Bell, but it really shouldn't even matter. The Jets' offense runs through Bell, especially with such a weak receiving core. He should have a nice fantasy day based off his heavy workload alone.
22. Raheem Mostert, San Francisco 49ers (vs. ARI)
Picking which 49ers running back will produce is never an easy task. But if you're going to pick one, it's probably Mostert. He was outstanding in 2019 and should pick up where he left off vs. the Cardinals in Week 1.
23. Jonathan Taylor, Indianapolis Colts (at JAC)
Taylor is someone I expect to be a league-winner this season. That said, I think it could be a slow start for the rookie as the Colts probably will give Marlon Mack most of the work out the gate. Still, Taylor's upside is impossible to ignore.
24. Cam Akers, Los Angeles Rams (vs. DAL)
Akers, like Taylor, probably will be eased into action and could take a backseat on the RB depth chart. The upside is absolutely there, but don't expect a ton of touches out the gate for the rookie.