NFL Week 8 picks: Latest spread, expert predictions for Patriots-Bills

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The New England Patriots will be battling injuries and bad weather in their crucial Week 8 road game against the Buffalo Bills on Sunday afternoon.

The forecast calls for heavy winds and steady rain, which could make passing the ball difficult for both teams. Injuries also will be a factor for the Patriots, who ruled out wide receivers Julian Edelman (knee) and N'Keal Harry (concussion) on Friday. Veteran wide receiver Damiere Byrd will be the No. 1 target for Patriots quarterback Cam Newton.

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History is on the Patriots' side, though -- they've completely owned this matchup over the last decade. The Pats have won seven consecutive games versus the Bills, and New England hasn't lost in Buffalo since 2011.

The Bills aren't playing particularly well at the moment, either. They struggled to beat the winless New York Jets in Week 7 and lost to the Kansas City Chiefs and Tennessee Titans in the two previous weeks by a combined score of 68-33.

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This weekend's showdown is a great chance for the Bills to silence their doubters and open a substantial 3.5-game lead over the Patriots for first place in the AFC East. If the Bills are going to earn the division crown for the first time since 1995, these are the types of games they must win.

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The latest betting lines for Patriots vs. Bills matchup are below -- Provided by our partner PointsBet

Spread: Bills -4 (-110), Patriots +4 (-110)

Moneyline: Bills -221, Patriots +175

Total: Over 41 points (+100), Under 41 points (-121)

Here's a roundup of expert predictions for Patriots vs. Bills in Week 8.

Mike Florio, ProFootballTalk: Patriots

Will Brinson, CBS Sports: Patriots

Pete Prisco, CBS Sports: Bills

Bill Bender, Sporting News: Bills

Gregg Rosenthal, NFL.com: Bills

Staff consensus, Bleacher Report: Bills

Nate Davis, USA TODAY: Bills

Jori Epstein, USA TODAY: Bills

Greg Cote, Miami Herald: Patriots

Sam Farmer, Los Angeles Times: Bills

Jenny Vrentas, MMQB (Sports Illustrated): Patriots

Albert Breer, MMQB (Sports Illustrated): Bills

Mina Kimes, ESPN: Bills

Mike Clay, ESPN: Bills

FiveThirtyEight: Bills 66 percent, Patriots 34 percent

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