The New England Patriots will need to overcome a hostile crowd and a much-improved Buffalo Bills team if they are going to leave New Era Field on Sunday as the top team in the AFC East.

First place in the division is on the line in Week 4 as the Bills host the Patriots in one of the most anticipated games in recent Buffalo history.

The defending Super Bowl champions have crushed opponents through the first three weeks of the season by a combined score of 106-17. Patriots quarterback Tom Brady has enjoyed a stellar start to the season, and he was even ranked by Pro Football Focus as the top QB in the league entering Week 4. New England's defense has been its biggest strength so far, leading the league in yards allowed and interceptions.

The Bills should present the toughest challenge for the Patriots to this point in the season. Buffalo has a very good run game, an excellent defense and a second-year quarterback in Josh Allen who is getting more and more comfortable in the offense with each passing week. Who will emerge from Sunday's matchup with an unbeaten record and first place in the division?

Keep it right here for all of the latest highlights, score updates, injuries and quick analysis from Patriots vs. Bills Week 4.

FINAL, 16-10 Patriots: An interception by Jamie Collins -- New England's fourth interception of the game -- seals a 16-10 win for the Patriots.

 

Fourth quarter, 2:00, 16-10 Patriots: We're at the 2-minute warning, and the Bills will have a first down at the Patriots' 40-yard line after the timeout. Stephen Gostkowski's missed extra point in the fourth quarter looms large.

Fourth quarter, 5:19, 16-10 Patriots: The Patriots take over with a little more than five minutes remaining. A long drive here could end the game.

Fourth quarter, 10:44, 16-10 Patriots: The Bills went for it on 4th-and-goal from the 2-yard line, and Matt Barkley's pass was incomplete. A huge stop for the Patriots defense.

Fourth quarter, 14:46, 16-10 Patriots: Jonathan Jones made helmet-to-helmet contact with Bills quarterback Josh Allen, which drew a 15-yard penalty on the Patriots cornerback. Allen went into the blue medical tent to be checked for a concussion, and backup quarterback Matt Barkley replaced him.

Third quarter, 0:10, 16-10 Patriots: The Patriots doubled their lead with a 23-yard field goal by Stephen Gostkowski. 

Earlier in the drive, Josh Gordon caught a 31-yard pass from Tom Brady.

Third quarter, 3:33, 13-10 Patriots: The Patriots defense has come up with its league-leading ninth interception of the season. J.C. Jackson picked off Josh Allen for the second time today, and he did a nice job keeping his feet inbounds along the sideline.

Third quarter, 5:27, 13-10 Patriots: The Patriots just punted to the Bills, who have a chance to take their first lead of the afternoon.

Patriots running back Rex Burkhead entered this game with a foot injury, and he hasn't seen much action so far.

Third quarter, 10:37, 13-10 Patriots: The Bills went 75 yards and converted on 4th-and-goal from the 1-yard line with a Josh Allen sneak to finally get into the end zone.

Third quarter, 15:00, 13-3 Patriots: The Bills start the second half with the ball.

Halftime, 13-3 Patriots: Bills kicker Stephen Hauschka missed a 49-yard field goal as time expired in the first half.

We also have an actual wedding for two Bills fans going on at halftime.

Second quarter, 1:17, 13-3 Patriots: Congrats to Frank Gore for reaching 15,000 career rushing yards.

Second quarter, 2:00, 13-0 Patriots: Let's look at some Tom Brady stats during the 2-minute warning.

Second quarter, 3:10, 13-0 Patriots: A couple injury notes for the Patriots.

Second quarter, 4:08, 13-0 Patriots: Tom Brady just threw his first interception of the season. It ended a 16-play drive that went 93 yards in 8:19. 

Second quarter, 10:33, 13-0 Patriots: Something to keep an eye on ahead of Week 5.

Second quarter, 12:27, 13-0 Patriots: Tom Brady hasn't played particularly well so far, especially when targeting his wide receivers.

First quarter, 0:02, 13-0 Patriots: One play after giving the Bills a first down on a 12-men-on-the-field penalty, Patriots cornerback J.C. Jackson intercepted Josh Allen to give the ball back to New England. So, to recap, Jackson has a punt block and a touchdown in the first quarter alone.

Allen is really struggling today.

He's also getting an earful from offensive coordinator Brian Daboll.

First quarter, 1:32, 13-0 Patriots: Here's another note on McCourty's interception.

First quarter, 6:22, 13-0 Patriots: Patriots defensive back J.C. Jackson blocked a punt, and Matthew Slater picked up the ball and ran it in for a touchdown.

Also, Bills quarterback Josh Allen has played awful so far. 

First quarter, 7:35, 6-0 Patriots: The Patriots have taken the lead! After a 26-yard completion from Tom Brady to James White -- Brandon Bolden scored on a 4-yard touchdown run. Patriots kicker Stephen Gostkowski missed the extra point -- his third consecutive game with a missed PAT. 

First quarter, 9:58, 0-0: Devin McCourty has intercepted another pass! The Patriots safety now has interceptions in each of the first four games of the season, tying him with team legend Mike Haynes for the longest interception streak in franchise history.

First quarter, 13:17, 0-0: The Patriots opened the game from their own 25-yard line, and running back Sony Michel picked up 15 yards -- his longest run of the season -- on first down. New England was forced to punt shortly after.

1:01 p.m.: The intensity before the game is very high!

12:47 p.m.: Patriots fans will be ready to run through a wall after listening to this Devin McCourty pre-game speech.

12:35 p.m.: Dave Portnoy of Barstool Sports is right in the middle of the Bills Mafia tailgating scene at New Era Field.

11:30 a.m. ET: Here are the inactives for both teams. 

PATRIOTS (3-0)

LB Dont'a Hightower
DB Joejuan Williams
RB Damien Harris
OL Caleb Benenoch
OL Korey Cunningham
QB Cody Kessler
DL Byron Cowart

BILLS (3-0)

RB Devin Singletary
WR Robert Foster
TE Tyler Kroft
T Conor McDermott
G Spencer Long
LB Corey Thompson
NCB Taron Johnson

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