Sony Michel left Sunday's game against the Bears after suffering a second-quarter knee injury.
Michel, whose fumble on the play led a Chicago recovery, was helped off the field.
Taken 31st overall in the 2018 draft, Michel missed all of the preseason before making his NFL debut in Week 2 against the Jaguars.
UPDATED: The Patriots announced at the start of the second half that Michel would not return to the game.