The Hawkeyes are through the regular season with an unblemished record.
Iowa got two long touchdown runs from Jordan Canzeri in the third quarter and bested Nebraska, 28-20, to stay undefeated at 12-0 ahead of next weekend's Big Ten Championship Game.
The Hawkeyes grabbed the early lead, scoring a touchdown on a 10-yard pass from C.J. Beathard to George Kittle. The Huskers followed that up when Desmond King fumbled a punt, setting up a short field for the Huskers, who scored shortly thereafter on a four-yard scoring run by Imani Cross.
But Iowa benefited from a Nebraska turnover not long after, Parker Hesse taking Tommy Armstrong's second interception of the game back for an easy go-ahead touchdown. Nebraska kicked a field goal before halftime to make it 14-10.
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After the break, the Canzeri Show really kicked off. Iowa got a big punt return from King and 15 more yards following a late hit. That set up Canzeri for a 29-yard touchdown run two plays later to boost the Hawkeyes' lead to 21-10.
Armstrong led the Huskers downfield on the ensuing drive, handing off to Cross for another four-yard touchdown run to again bring Nebraska within four. But on the first play of the next Iowa drive, Canzeri streaked past the Nebraska defense for a 68-yard touchdown run to grow the lead back out to two scores.
Later in the second half, Armstrong threw another interception, then Mike Riley caused heads to be scratched everywhere, calling a deep throw to the end zone on a fourth and one from the Hawkeyes' 19-yard line in the fourth quarter. That pass was broken up, turning the ball over. Nebraska forced an Iowa punt on the next drive, but Armstrong's first pass was again intercepted, his fourth pick of the game.
The Huskers added a late field goal with less than a minute and a half to play, but the onside kick was gobbled up by the Hawkeyes, who kneeled it for the victory.
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Nebraska out-gained Iowa by a big margin, 433-250, but Armstrong's four picks proved back-breakers. The Hawkeyes had a 153-137 edge in rushing yardage.
Canzeri finished with 140 yards and a pair of touchdowns on 17 carries, while Beathard completed just nine passes for 97 yards and a touchdown.
Armstrong completed 25 of his 45 passing attempts for 296 yards and zero touchdowns, pitching those four interceptions. Cross had just 55 yards but two touchdowns on 19 carries.
The four Hawkeyes to come away with interceptions: Hesse, Greg Mabin, Josey Jewell and Cole Fisher.
Iowa completed its regular-season schedule with a perfect 12-0 record, and the Hawkeyes will take on either Michigan State, Ohio State or Michigan in next weekend's conference title game in Indianapolis. This is the fifth undefeated regular season and the first 12-win season in Iowa program history.
Nebraska missed bowl eligibility with the defeat, finishing with a 5-7 record in Riley's first season as head coach. It's the first 5-7 finish and season without a bowl appearance at Nebraska since 2007, Bill Callahan's final year as head coach.