Christian McCaffrey (RB2) -- Coach Ron Rivera openly admitted team's desire to lighten McCaffrey's load but only added replacement pieces in fifth-round plodder Jordan Scarlett and UDFA Elijah Holyfield. Emphasis on conditioning this offseason arguably preps Run CMC to handle back-to-back every-down campaigns.
Ezekiel Elliott (RB3) -- Unleashed for career-highs in targets (6.3) and routes run (27.3) per game last year, Elliott's usage out of the backfield presumably rivals any of Best-Ball's elite options.
Alvin Kamara (RB4) -- Inconsistent production once Mark Ingram returned from suspension in Week 5, but week-winning ceiling still a no-brainer top-four lock despite offseason addition Latavius Murray inevitably playing Ingram's role in '19.
David Johnson (RB5) -- With ex-coach Steve Wilks' ancient up-the-gut approach now an afterthought, DJ should return to fantasy dominance in Arizona's uptempo "90 - 95 plays per game" assault. Kliff Kingsbury's offenses averaged 26.1 running back carries per game in his final two seasons at Texas Tech (not to mention a Division 1-high 82 plays per game in KK's six years in Lubbock).
Melvin Gordon III (RB6) -- Averaged a bellcow-like 15.9 carries and 6.4 targets through the Chargers' first nine games before an MCL sprain Thanos'd his season into dust.
Joe Mixon (RB7) -- Fantasy's RB10 showcased on 69.7% of Cincy's offensive snaps in bounce-back sophomore campaign.
Le'Veon Bell (RB8) -- Now that all the smoke has cleared, 2018's holdout quietly a positive for Bell's season-long outlook following an absurd 406 touches from the year prior.
James Conner (RB9) -- Called upon to be an every-down back and responded across the board with 16.5 carries and 5.5 targets per game in 13 starts last season.
Todd Gurley (RB10) -- Whether it's degenerative arthritis, No. 70 overall pick Darrell Henderson's presence, or the Rams' curious decision to match Detroit for the rights to Malcolm Brown, all signs point to Gurley plunging to the third round by August.
Leonard Fournette (RB12) -- Sneakiest three-down back in all of football when healthy last year. Hamstring strain that held him out remains completely unrelated (and thus indifferent) to past complications with foot and ankle.
Derrick Henry (RB13) -- Fantasy's RB1 over the final five weeks averaged an ungodly 19.4/125/1.6 in December.
Dalvin Cook (RB14) -- If opportunity were a crown, Cook is arguably the offseason's king following Latavius Murray's departure. The fact he's played six fewer games than Fournette since the two came into the league together remains worrisome.
Devonta Freeman (RB15) -- Expected to soak up a 70/30 role ahead of Ito Smith. Falcons quietly have 170 carries (48.4%) unaccounted for from last season's production due in part to Tevin Coleman's departure.
Marlon Mack (RB16) -- 17.3 carries per game as Indy's lead horse from Week 7 on. Primary beneficiary of coach Frank Reich's insistent undertaking to become a more efficient running team this upcoming year.
Damien Williams (RB17) -- Five-week wonder rocketed to fantasy stardom with 26.2 points per outing from Week 15 on (playoffs included).
Aaron Jones (RB18) -- 20.2 fantasy points per game in seven post-bye week starts, but standout second-half short was cut short in Week 15 due to a sprained MCL. Will still start the year completely entrusted over incumbent backup Jamaal Williams simply due to Jones' natural ability as an outside zone runner in OC Nathaniel Hackett's one-cut scheme.
Kerryon Johnson (RB20) -- Talent alone will propel Johnson to RB2-status, but his between-the-20's role remains discouraging (and overvalued) at his current fourth-round ADP.
Derrius Guice (RB21) -- Direct path to lead duties if fully recovered from last season's torn ACL.
Phillip Lindsay (RB24) -- RB9 from Weeks 7 - 15 before ligament damage cut his season short. Remains questionable for training camp. Offseason reports of timeshare with Royce Freeman are concerning for Lindsay's floor.
James White (RB25) -- A non-factor to close the year but passing-game usage still lends a high weekly ceiling that's perfect for Best-Ball formats.
Mark Ingram II (RB26) -- $6.5 million guaranteed slides Ingram atop this depth chart, but potential four-man committee remains a looming question mark for his usage. A safe floor-bet given Baltimore's league-high 64 percent run play rate once Lamar Jackson went under center.
Sony Michel (RB28) -- Red-flag knee scope this offseason follows a lengthy injury history including a high-school ACL tear, Grade 1 Knee Sprain in the 2017 SEC Championship, fluid drainage from his knee last August, and a left knee injury back in October.
Tevin Coleman (RB29) -- Proven fit as an explosive committee-back should allow Coleman to transition seamlessly into San Francisco's backfield. Arguably ahead of the pack entering training camp given Matt Breida's (pec) and Jerick McKinnon's (ACL, "lightly running") current injury situations.
David Montgomery (RB30) -- Long-shot to lead Chicago's trio of backs in both carries and targets, but has received glowing reports of his route running in minicamp.
Tarik Cohen (RB32) -- Spiked four top-six finishes at his position in '18 despite part-time role.
Lamar Miller (RB33) -- You know what you're getting, for better or worse.
Miles Sanders (RB34) -- Hand-picked by analytically-driven front office to inevitably lead this backfield in carries in his rookie year.
Rashaad Penny (RB35) -- Seattle's No. 27 overall pick splashed surprising explosiveness on limited touches in his rookie year. Supposed "one-two punch" with Carson to open the 2019 season after working out with Marshall Faulk in the offseason and reporting to minicamp at a trimmed 228.
Royce Freeman (RB36) -- GM John Elway recently noted the Broncos "feel like they have a good 1-2 punch" in Lindsay and Freeman. Offseason speculation suggests Denver's 2018 third-rounder out-carries Lindsay this upcoming year. Quietly received numerous reps in the passing-game at minicamp.
Matt Breida (RB38) -- The Bay Area's real-life Ironman remains the early favorite to lead this backfield in carries despite his lagging ADP (143.8).
Jordan Howard (RB39) -- Eagles RB coach Duce Staley, OC Mike Groh, and coach Doug Pederson all complimented Howard’s pass-catching ability as he was “targeted frequently” at OTAs.
Jerick McKinnon (RB40) -- Best-case scenario at this point may be McKinnon finding a home elsewhere. All guaranteed cash from his four-year, $30 million deal has already been doled out.
Mike Davis (RB41) -- Early beat speculation projects Davis with 120 carries.
Kareem Hunt (RB42) -- Proven talent with field-flipping athleticism but likely won't make an impact until final quarter of season.
Damien Harris (RB43) -- Versatile prospect with a limited-ceiling being given the benefit of the doubt since he landed under Bill Belichick's tutelage. Speculation he'll open the year with Michel's early-down role given the latter's knee injury.
Austin Ekeler (RB44) -- Double-digit fantasy points in 5-of-7 games out the gates in 2018 despite being pigeon-holed as the team's clear-cut backup.
D'Onta Foreman (RB45) -- Will undoubtedly be given every opportunity to buck the trend of inefficiency and loss of explosiveness coming off of Achilles' tear.
Peyton Barber (RB46) -- Shouldn't be written off given his team-high 234 carries just last year.
Nyheim Hines (RB48) -- Averaged 8.5 targets in four games sans Mack. Only 3.9 looks in the world's greatest disappearing act in his other 12 outings. Rookie Parris Campbell's versatility threatens Hines' chess-piece role.
Jaylen Samuels (RB50) -- Averaged a hellacious 6.0 yards per touch as an every-down back in three starts for Conner, but was an afterthought in every other contest.
Kalen Ballage (RB51) -- Ex-coach Adam Gase's fourth-round prospect, Ballage has yet to separate himself from the committee-back label that's followed him since his collegiate years at Arizona State.
Devin Singletary (RB52) -- Can overcome lackluster combine results if given an opportunity in crowded backfield. Reportedly Buffalo's "breakout star" at OTAs.
Justice Hill (RB53) -- 4.40 40-time the perfect fit for coach John Harbaugh's "home-run" backfield role.
Chris Thompson (RB54) -- One-season removed from averaging 15.9 fantasy points per game over a monstrous 10-game stretch before breaking his fibula.
Adrian Peterson (RB55) -- Banking on back-to-back 1,000-yard seasons from 34-year-old Peterson seems less than ideal.
Ito Smith (RB56) -- 'The Judge' may have taken on Devonta Freeman's touches in the latter's stead, but he looked more like T.J. Duckett when hitting the open field. Exceeded nine fantasy points in just 4-of-12 games without Freeman last season.
Dion Lewis (RB57) -- 6.7 fantasy points per game in a reduced role behind Henry last December.
Duke Johnson Jr. (RB58) -- Outside chance Duke gets traded (and thus returns value) by training camp.
Jalen Richard (RB59) -- Expected to get the initial nod over Jacobs for third downs.
Jamaal Williams (RB60) -- New Packers coach Matt LaFleur has already staked his claim that a "committee approach" is the most effective way to get the most out of Jones and Williams, but the latter's between-the-tackles prowess could open the door for rookie Dexter Williams to become the 1B option.
T.J. Yeldon (RB61) -- Pending McCoy's involvement, Yeldon is arguably guaranteed third-down snaps as the only pass-catching back on the roster.
Doug Martin (RB62) -- Led Oakland in carries (172) just last year. Raiders invested a Day One pick in Jacobs, but old-school tribalism mindset could result in Gruden sticking with what (or in this case, who) he knows.
C.J. Anderson (RB63) -- Leading Detroit's backfield in rushing scores well in his range of outcomes.
Malcolm Brown (RB64) -- The assumption is Los Angeles matched Detroit's $3.25 million contract for a reason.
Trayveon Williams (RB65) -- Will likely sit behind Bernard and watch the latter's contract-year play out, but new coach Zac Taylor could get an early look at his sixth-round project down the stretch.
Darwin Thompson (RB66) -- Undersized (5'8", 198) but chiseled, Thompson's already asserted himself as a "change of pace" runner in rookie camp.
Alfred Blue (RB69) -- Workhorse-role in the (likely) event Fournette misses time not an issue as Blue has quietly averaged 135 carries per year over the last five seasons.
Giovani Bernard (RB70) -- Regime shift could be just the change Gio needs to stand out as a proven vet capable of producing standalone value behind Mixon.
Rex Burkhead (RB71) -- Early rumblings suggest Burkhead as the odd man out among New England's five backs.
Chase Edmonds (RB72) -- All-around versatility going from being used in the league's most stone-aged offense to a visionary one.
Elijah McGuire (RB73) -- One Le'Veon ailment away from returning to a workhorse role.
Justin Jackson (RB74) -- Totaled 85 yards and one score on 19 touches in his lone start last year.
Gus Edwards (RB745 -- Lack of receiving chops in a four-headed timeshare renders Edwards useless (barring an injury) from a fantasy standpoint.
Kenneth Dixon (RB76) -- Gifted athletic traits to wreak havoc in outside chance he usurps Hill for third-down role.
Benny Snell Jr. (RB77) -- Classic tape-versus-spreadsheet evaluation conundrum. Snell's motor could still be utilized if Conner were to miss any time.
Frank Gore (RB78) -- Don't have to squint to see Gore adding another "Team-High in Carries" trophy to his mantle.
Bryce Love (RB79) -- Reported knee stiffness stemming from ACL tear in regular season finale at Stanford, but lands in favorable destination with median competition.
Alexander Mattison (RB80) -- Whether it was a wise decision or not (it wasn't), Vikings invested a third-round selection to have Mattison handcuff Cook as early as this year.