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Brandon Aiyuk gives 49ers 7-3 lead on Cardinals

Chris Simms and Ahmed Fareed preview the Monday night matchup from Mexico City between the 49ers and Cardinals, and whether Arizona can keep things close.

49ers receiver Brandon Aiyuk scored his fifth touchdown of the season, matching his touchdown total from his 2020 and 2021.

The 49ers receiver caught a 7-yard touchdown pass from Jimmy Garoppolo with 13:35 remaining in the second quarter. It has given the 49ers their first lead, 7-3, after the Cardinals got an early field goal.

San Francisco went 82 yards in nine plays, only their second 80-plus-yard drive of the season.

Jonathan Ledbetter was called for a facemask penalty on Christian McCaffrey, giving the 49ers a free 15 yards in the drive, but replay showed Ledbetter did not get McCaffrey’s facemask.

Garoppolo is 7-of-10 for 57 yards and a touchdown. Deebo Samuel has three catches for 28 yards, and McCaffrey has five carries for 31 yards and two catches for 16 yards.

The Cardinals got a 40-yard field goal from Matt Prater in the first quarter.