Freeman also scored two touchdowns during the 42-35 win over the Cornhuskers at Autzen Stadium.
Freeman entered the season with 4,146 career rushing yards and needing 937 to break LaMichael James' record of 5,082 (2009-2011).
Here is a quick look at where Freeman's chase stands:
James' record: 5,082 yards.
Last week: Freeman rushed for 153 yards on 29 carries and scored two touchdowns vs. Nebraska.
Previous games: Freeman Rushed for 150 yards vs. Southern Utah.
2017 total: Freeman has rushed for 303 yards in two games.
Career total: Freeman now has 4,449 yards rushing.
Freeman needs: He is 634 yards away from breaking James' record.
James' record: 53.
Last week: Freeman rushed for two touchdowns.
2017 total: six.
Career total: Freeman has 50 rushing touchdowns for his career.
Freeman needs: He is four away from breaking James' record.
Next up: The Ducks play at Wyoming (1-1) Saturday in Laramie, Wy.