How to watch Eagles vs. 49ers in Week 2


It would be hard to draw up a better start to the Nick Sirianni era than what happened Week 1 in Atlanta. 

Siranni’s Philadelphia Eagles were firing on all cylinders in their 2021 season opener as they crushed the Falcons 32-6. Jalen Hurts impressed in his debut as the franchise’s full-time starter, DeVonta Smith flashed his WR1 potential and the offensive line showed just how dominant it can be at full strength. On the defensive side of the ball, Jonathan Gannon’s unit held Matt Ryan and Co. to 260 total yards and didn’t allow them to reach the end zone.


The 1-0 Eagles are now set for their first regular-season game in front of a full capacity Lincoln Financial Field crowd since January 2020. And they’ll need a boost from their home fans with the San Francisco 49ers coming to town.

The Birds beat the 49ers 25-20 in Week 4 last season, but that was with Nick Mullens and C.J. Beathard playing quarterback for San Francisco. The 49ers will have Jimmy Garoppolo, along with stud defensive end Nick Bosa, this time around as they look primed for a run to the playoffs. 

San Francisco is also 1-0 after jumping out to a 31-10 lead over the Detroit Lions and holding on for a 41-33 victory in Week 1. Garoppolo threw for 314 yards and one touchdown while rookie sixth-round Elijah Mitchell rushed for 104 yards and one score in relief of Raheem Mostert, who suffered a season-ending knee injury.

Here is what you need to know ahead of the Eagles’ home opener against the 49ers:


What time do the Eagles play in Week 2?

Kickoff between the Eagles and 49ers is set for 1 p.m. ET on Sunday, Sept. 19, at Lincoln Financial Field in Philadelphia.

What TV channel is the Eagles game on?

Eagles-49ers will air on FOX. Adam Amin (play-by-play), Mark Schlereth (analysis) and Shannon Spake (sideline reporter) will be on the call.

Start your football Sunday at 9:30 a.m. ET with Eagles Game Day Kickoff on NBC10, followed by Eagles Game Plan at 10 a.m. NBC Sports Philadelphia’s Eagles coverage, which you can stream live here and in the MyTeams app, begins at 11:30 a.m. with Birds Huddle, followed by Eagles Pregame Live at 12 p.m. Come back to NBCSP after the game for Eagles Postgame Live.

How to stream Eagles vs. 49ers live online

Live stream: FoxSports.com, NFL Game Pass

Mobile app: Yahoo! Sports app, NFL mobile app

Free streaming option: FuboTV (free trial)

How to listen to Eagles vs. 49ers on the radio

Station: SportsRadio 94WIP


Are the Eagles the favorite against the 49ers?

Despite their dominant Week 1 showing, the Eagles enter Sunday’s game against the 49ers as three-point home underdogs, according to our partner, PointsBet

Moneyline: 49ers -150, Eagles +130

Check out the full betting preview for the game here.

Editor's note: All odds are provided by our partner, PointsBet. PointsBet is our Official Sports Betting Partner and we may receive compensation if you place a bet on PointsBet for the first time after clicking our links.