The Eagles haven't fared well against Washington in recent years. In fact, the Birds have lost their last five contests against their division rival, including both games last season.
The two losses against Washington last season came by a total of 12 points.
This is a big game for the Eagles. A win could start off their season on the right track, especially before a really tough game against the Chiefs on the road in Week 2.
So here's a look at five matchups that will play a major role on Sunday afternoon at FedEx Field:
Lane Johnson vs. Ryan Kerrigan
You probably remember what happened in the first matchup between the Eagles and Washington last year. Back on Oct. 16, Johnson's 10-game PED suspension kicked in and the Eagles were left with rookie Halapoulivaati Vaitai at right tackle. Eventually, Vaitai ended up having a pretty decent rookie season but it didn't get off to a great start. In fact, his introduction to the NFL was pretty ugly and he can thank Kerrigan for that. Carson Wentz was sacked five times in the game and half of them belonged to the veteran pass rusher.
After missing both games against Washington in 2016, Johnson is back and hoping for a little revenge. In fact, he's already said the Eagles are going to "whup some ass" in the opener.
"First of all, [Kerrigan] is a great player," head coach Doug Pederson said. "He's a high-motor guy, a relentless finish. That's what you have to identify with him. It's good to have Lane back. Obviously, that was V's first start last year and he struggled in the game. To have Lane back, a little confidence there. Should be a good matchup all day, and just have to give the guy respect. He's a good pass rusher."
Jamison Crowder vs. Patrick Robinson
After a terrible start to training camp, Robinson rebounded once Ronald Darby was acquired. That move pushed him inside and he found a home in the slot position for the Eagles. For the most part, that will be a position by committee this season, but against a shifty player like Crowder, Robinson should get first crack, while Malcolm Jenkins will have to deal with tight end Jordan Reed.
For as much attention as DeSean Jackson and Pierre Garcon got over the last couple years, Crowder has turned into a really solid option. He had 67 catches for 847 yards and seven touchdowns in 2016. Against the Eagles last year, he had five catches for 89 yards and a touchdown. He's a big part of Washington's offense.
Brandon Scherff vs. Fletcher Cox
Scherff, Washington's right guard, went to his first Pro Bowl in 2016, a year after he was taken in the first round out of Iowa. It's a big matchup, because there's a good chance Scherff will go 1-on-1 against Cox, who doesn't see a ton of 1-on-1 matchups anymore.
"[Scherff] does the little things right," Cox said. "You just have to study him and watch the things that he's gotten beat on. Just study him and just study their line because I think they have a solid group of guys that play together on the same page."
Kirk Cousins always seems to bring his best games against the Eagles, so Cox's ability to generate pressure could potentially change the game.
Zach Ertz vs. Redskins safeties
Ertz had one bad game against Washington in 2016 and one great game. In the first matchup, he had one catch for 22 yards, but the next time, he had 10 for 112. Of course, that second game was in December, when Ertz seems to come alive. But there will be chances for Ertz on Sunday, especially because Washington will be without safety Su'a Cravens, who is contemplating retirement. That leaves Washington with D.J. Swearinger and Deshazor Everett at safety. Neither are known for their cover skills.
Alshon Jeffery vs. Josh Norman
Expect Norman to travel and stick with Jeffery for the entire game on Sunday. Washington head coach Jay Gruden on Wednesday said he didn't know if that's what he would do, but it seems pretty clear that's what will happen.
Last year when Jeffery faced Washington as a member of the Bears, Norman stayed with him all game. Jeffery ended the game with five catches on 10 targets for 92 yards.
"Alshon won his share and Josh won his share," Pederson said. "It's a good battle. I think those two have a lot of respect for each other and it's great competition."