Andre Brown's fractured left leg is expected to keep him out 4-6 weeks, making a Week 3 return the best-case scenario.
49ers RB LaMichael James has been diagnosed with a sprained MCL and will be sidelined three weeks. Week 3 could be a possible return date, but Week 4 against the Rams seems more realistic.
Chargers WR Robert Meachem suffered a concussion in Thursday night's preseason finale, possibly expediting his ticket out of San Diego.
The Cardinals have placed LG Jonathan Cooper on injured reserve with a fractured fibula, effectively ending the season of the 2013 seventh-overall pick.
During the Bills' third preseason game, QB Kevin Kolb took a knee to the head. Kolb has been diagnosed with a severe concussion, which may end his career.
During an interception return against the Jets on Saturday, Giants safety Stevie Brown tore his ACL and will miss the entire 2013 season.
Reports indicate Mark Sanchez's injury has been diagnosed as a bruised right shoulder joint and is considered day to day.
Bills CB Stephon Gilmore (broken wrist) will undergo surgery and be sidelined 6-8 weeks.
Seahawks third-round DT Jordan Hill is out 3-6 weeks with a partial biceps tear.
Bucs kicker Lawrence Tynes underwent toe surgery this week to remove a staph infection.
Giants OL David Diehl underwent successful thumb surgery and will be out six weeks.
Giants WR Victor Cruz has been diagnosed with a heel contusion and is now using crutches. He is expected to miss the rest of preseason play.
Steelers RB Le'Veon Bell is not expected to have surgery for his Lisfranc injury, but it looks like Bell will be out for at least 6-8 weeks.
Redskins QB Kirk Cousins suffered a mid-foot sprain in Monday night's preseason game against the Steelers.
Jaguars QB Blaine Gabbert has a hairline fracture in his right thumb that will sideline him for the remaining weeks of the preseason.
Colts TE Coby Fleener will undergo a precautionary MRI on his sprained knee. Fleener is highly questionable for Saturday's regular season dress rehearsal against the Browns.
Jets OLB Quinton Coples fractured his ankle in New York's preseason game and could be sidelined 3-4 weeks.
Broncos LCB Champ Bailey suffered a foot injury in Denver's preseason game and is on crutches. X-rays came back negative, but Bailey is headed for an MRI.
Dolphins TE Dustin Keller is done for the season after suffering a knee injury in Miami's preseason game against the Texans.
Chargers WR Eddie Royal has been diagnosed with a bruised lung and concussion that he sustained in practice.
Kendall Wright has avoided a ligament tear in his right knee, but will still require 2-4 weeks of rehabilitation.
DeAndre Hopkins has been officially diagnosed with a concussion and is highly questionable for the Texans' next preseason game.
All but wrapping up the starting job, E.J. Manuel will undergo a minor knee procedure and miss the rest of the preseason. Manuel will likely need his knee scoped, so his Week 1 status is questionable. He will be re-evaluated at the end of the preseason.
The Saints ILB will undergo a knee scope and miss the rest of the preseason. Vilma is expected to be ready for Week 1.
Cowboys guard Ronald Leary will have his knee scoped and is "iffy" for the season opener.
Browns RG Jason Pinkston was diagnosed with a "severe" high ankle sprain. Pinkston is doubtful for Week 1 and could be out for much longer than that.
Cardinals free safety suffered a sprained ankle and MCL and is considered week-to-week at this point. Johnson's injury creates an opportunity for rookie Tyrann Mathieu, who is expected to start against the Cowboys.
Already dealing with a dislocated thumb, Montario Hardesty will undergo a knee scope and two weeks of rehab
The Redskins have placed safety Phillip Thomas on injured reserve with a left Lisfranc fracture, ending his season.
Giants FS Antrel Rolle is in a walking boot, but avoided a high-ankle sprain. Rolle is firmly on track for a Week 1 return.
Despite avoiding a ligament tear, Malcom Floyd’s severely sprained knee could keep him sidelined for more than a month, potentially hindering his Week 1 status.
Chiefs running back Jamaal Charles had to be carted off the practice field after injuring his foot. X-rays were reportedly negative and head coach Andy Reid referred to the injury as a strain. The timetable for his return is uknown at the moment.
Indianapolis Colts TE Dwayne Allen will miss a few weeks of action, after injuring his foot in the Colts' first preseason game against the Buffalo Bills.
After playing nine snaps against the Seattle Seahawks in the Chargers' first preseason game, LB Manti Te'o will miss a week with an injured foot.
Cardinals running back Rashard Mendenhall injured his knee and is questionable for Arizona's slate of remaining preseason games. Mendenhall is also probable for Week 1 of the regular season.
Plaxico Burress suffered a torn rotator cuff in his shoulder during practice and will go under the knife, ending his season.
Rams RT Rodger Saffold dislocated his left shoulder in St. Louis' preseason opener and is expected to be miss a few preseason games.
Bernard Scott has been slow to recover from a left ACL tear suffered last October, giving the running back a good shot at starting the season on the PUP list.
Facing a six-to-eight month recovery, the Bears placed CB Kelvin Hayden on injured reserve with a torn left hamstring, ending the nine-year veteran's season.
A.J. Green (knee) has been ruled out for the preseason opener versus the Falcons.
Eagles WR Arrelious Benn (Eagles) has been diagnosed with a torn left ACL, and is done for the season.
A second medical opinion confirmed Packers LT Bryan Bulaga will need surgery on his ACL tear and is done for the season.
Danario Alexander has been diagnosed with a torn right ACL, and is done for the season.
ESPN's Adam Schefter reported on NFL Insiders that the Texans are confident Arian Foster (calf, back) will be okay ahead of Week 1 despite his continued practice absences.
ESPN's Adam Schefter reported on NFL Insiders Tuesday that the "buzz is positive" regarding Rob Gronkowski's recovery from back surgery.
The Seahawks are "even more hopeful" Percy Harvin will play at some point this season after getting information from his hip surgery.
The Associated Press reports that Colts spokesman Avis Roper said that Heyward-Bey’s knee injury, which he suffered in practice on Sunday, was “not serious.” The team did not offer any exact idea about what that determination means in terms of a timeline for Heyward-Bey’s return to practice.
Saints WR Joe Morgan has been diagnosed with a torn meniscus and partially torn ACL and is done for the season.
Coach Mike McCarthy reiterated the Packers are "hopeful" Jordy Nelson (knee surgery) will be ready for Week 1.
Giants RE Jason Pierre-Paul (back surgery) says being ready for Week 1 is "not important to me at all."
Kolb tripped on a wet mat this morning and exited practice. While the injury isn't serious, this opens the door for E.J. Manuel to get more reps in the coming days. Aug 3 - 10:44 AM
Jeremy Maclin (torn ACL, injured reserve) underwent successful surgery on Tuesday, August 6, 2013.
Dennis Pitta did not suffer any ligament or cartilage damage when he fractured and dislocated his hip but is done for the year.
ESPN's Adam Schefter reported on NFL Insiders that the Jets are optimistic Santonio Holmes (foot) will not miss the first four games of the season, as Holmes had allegedly told people around him.
A league source tells Profootballtalk.com the Bills' "current assumption" is Stevie Johnson's strained hamstring will cost him "most of the preseason."
Panthers placed RB Jonathan Stewart (ankles) on the active/PUP list.
Trent Richardson (shin) has yet to return to team drills, and is expected to sit out the preseason opener on Thursday, August 8, 2013.
49ers ILB Patrick Willis will require surgery on his slightly fractured right hand.
Broncos placed C Dan Koppen on injured reserve with a torn left ACL, ending his season.