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Two NASL sides left as U.S. Open Cup begins Round of 16

2015 Lunar New Year Cup - South China v New York Cosmos

SO KON PO, HONG KONG SAR - FEBRUARY 19: Daniel Szetela (R) of New York Cosmos and Siu Kwan Chan of South China in action during the 2015 Lunar New Year Cup match between South China and the New York Cosmos at Hong Kong Stadium on February 19, 2015 in So Kon Po, Hong Kong. (Photo by Victor Fraile/Getty Images)

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American soccer’s second tier is seeking a return to the Lamar Hunt U.S. Open Cup quarterfinals after a year away, and pins its hopes on two NASL sides.

The Open Cup has not had a non-MLS semifinalist since the third tier Richmond Kickers made it into the final four in 2011.

Major League Soccer clubs joined the tournament in the fifth round and promptly defeated all underdogs not named New York Cosmos and Fort Lauderdale Strikers.

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Those two North American Soccer League sides hope to be left standing in the quarters come Wednesday. The remaining six matches are MLS vs. MLS affairs, with the tournament winner moving onto the 2017-18 CONCACAF Champions League.

Tuesday matches
Chicago Fire vs. Columbus Crew -- 8:30 p.m. ET
Real Salt Lake vs. Seattle Sounders -- 10 p.m. ET

Wednesday matches
Philadelphia Union vs. New York Red Bulls -- 7 p.m. ET
Houston Dynamo vs. Sporting KC -- 7 p.m. ET
Orlando City vs. Fort Lauderdale Strikers -- 7:30 p.m. ET
New York Cosmos vs. New England Revolution -- 7:30 p.m. ET
FC Dallas vs. Colorado Rapids -- 8:30 p.m. ET
Portland Timbers vs. L.A. Galaxy -- 10:30 p.m. ET

Follow @NicholasMendola