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Vincent Kompany lasts just six minutes against Dynamo Kiev

Manchester City FC v FC Dynamo Kyiv - UEFA Champions League Round of 16: Second Leg

MANCHESTER, ENGLAND - MARCH 15: An injured Vincent Kompany of Manchester City (4) in discussion with team mates Pablo Zabaleta (L) and Joe Hart (R) during the UEFA Champions League round of 16 second leg match between Manchester City FC and FC Dynamo Kyiv at the Etihad Stadium on March 15, 2016 in Manchester, United Kingdom. (Photo by Laurence Griffiths/Getty Images)

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The second leg of Manchester City’s Champions League matchup with Dynamo Kiev got off to a terrible start for the Citizens as captain Vincent Kompany was forced off just six minutes into the match.

Kompany pulled up while running in for a challenge, going down and immediately signaling to the bench for a substitution.

[ FOLLOW LIVE: UCL scores, stats ]

It looked to be a recurrence of a calf problem that has bothered the big Belgian all season long. Kompany missed more than a month with a calf injury before Christmas, only to re-injure himself just minutes into his return on Boxing Day. He then missed a further eight weeks of play.

City lead Dynamo 3-1 on aggregate and should go through, although this injury could be a massive blow to their hopes in the Premier League, especially with the Manchester derby this weekend.

UPDATE: Nicolas Otamendi also went down injured, forcing Manuel Pellegrini to substitute both of his starting center-backs within the opening 25 minutes.