Cornerback Jimmy Smith will miss his third game of the season after suffering an ankle injury at New England on Monday night, the team officially announced on Sunday.
Smith, who did not practice all week and was declared out for the game on Friday, is among the Ravens seven game-day inactives.
The other inactives for the Ravens include running back Buck Allen, offensive linemen Ryan Jensen and Alex Lewis, tight end Crockett Gillmore, linebacker Za'Darius Smith and newly signed linebacker Lamar Louis.
Gillmore, who had missed six straight games with a thigh injury, returned to practice this week but hasn't played since mid-October, and the Ravens already have three healthy tight ends in Dennis Pitta, Darren Waller and Nick Boyle.
With Smith sidelined, Shareece Wright is expected to start at cornerback along with rookie Tavon Young.
Cornerback Jerraud Powers, who was listed as questionable this week with a concussion, is active and expected to play.
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For the Eagles, running back and return threat Darren Sproles is out with a concussion.
The Eagles are also without starting right tackle Halapoulivaati Vaitai (knee) and starting left guard Allen Barbre (hamstring).
The Eagles other inactives are wide receiver Paul Turner, cornerback Dwayne Gratz, defensive end Steven Means and defensive tackle Taylor Hart.