It's officially the semi-finals of most fantasy football playoffs! Where did the time go?

There's no margin for error anymore. With the postseason here, every start, sit and roster move matters. 

So, who can we trust in Week 16? Here are the best wide receivers to start in fantasy football this week...

All rankings are in the points-per-receptions (PPR) format.

Byes: None

2021 FANTASY FOOTBALL WR RANKINGS: WEEK 16

Week 16 rankings: Quarterbacks | Running Backs | Wide Receivers | Tight Ends | Defense/Special Teams 

1. Cooper Kupp, Los Angeles Rams (at Vikings)

• 2021 stats: 122 receptions, 1,625 yards, 14 touchdowns

Cooper Kupp is on pace for the best fantasy football season by a wide receiver ... ever. Kupp's worst game this season came in Week 4, where he finished with five catches for 64 yards. In every other game this season, Kupp has finished with seven-plus catches and 92-plus yards. That's simply unheard of. 

2. Davante Adams, Green Bay Packers (vs. Browns)

• 2021 stats: 96 receptions, 1,248 yards, 8 touchdowns

Davante Adams was limited to just 44 yards this past week, as the Ravens seemed to double-team the Green Bay star wideout on every snap. Still, though, Adams projects to have a big game against Cleveland this weekend. Play him as a WR1.

3. Justin Jefferson, Minnesota Vikings (vs. Rams)

• 2021 stats: 89 receptions, 1,335 yards, 9 touchdowns

No wide receiver in NFL history has recorded more receiving yards over their first two seasons than Justin Jefferson. The two-time Pro Bowler has been exceptional for Minnesota this season, especially with Adam Thielen sidelined the past few weeks. With Thielen expected to return to the lineup this week, Jefferson should have more 1-on-1 opportunities, even if Rams star Jalen Ramsey decides to shadow him. Jefferson is a high-end WR1 this week.

4. Tyreek Hill, Kansas City Chiefs (vs. Steelers)

• 2021 stats: 102 receptions, 1,178 yards, 9 touchdowns

Tyreek Hill had a monster game last Thursday against the Chargers, finishing with 12 catches for 148 yards and a touchdown. Hill is currently on the reserve/COVID-19 list, but there's a chance he can clear protocols before Sunday's game vs. Pittsburgh. If Hill is able to return, he's a high-end WR1 against a Steelers defense that has been inconsistent this season.

5. Diontae Johnson, Pittsburgh Steelers (at Chiefs)

• 2021 stats: 86 receptions, 1,028 yards, 6 touchdowns

Diontae Johnson has been one of the biggest breakout stars of the 2021 season. Johnson has totaled 10-plus targets in all but three games this season and has the third-most targets of any player this year. Johnson has a tough fantasy matchup this week against a Chiefs defense that has been on fire as of late, but the third-year wideout should still turn in a solid outing.

6. Deebo Samuel, San Francisco 49ers (at Titans)

• 2021 stats: 57 receptions, 1,028 yards, 11 touchdowns

There's arguably no player that has been more efficient with his touches this season than Deebo Samuel. The 49ers do-it-all star has played more running back than wideout in recent weeks, yet has still managed a way to remain effective and find the end zone. Samuel is poised for another big day this Thursday against the Titans.

7. CeeDee Lamb, Dallas Cowboys (vs. Washington)

• 2021 stats: 70 receptions, 940 yards, 6 touchdowns

Sorry, Amari Cooper, CeeDee Lamb is the Cowboys' clear No. 1 wideout. He's totaled 32 targets over the past two games -- the most of any Dallas wideout by a significant margin. With Washington potentially without its top two cornerbacks in Kendall Fuller and William Jackson III, play Lamb as WR1 this Sunday.

8. Keenan Allen, Los Angeles Chargers (at Texans)

• 2021 stats: 92 receptions, 1,007 yards, 5 touchdowns

Since Week 8, Keenan Allen has been one of the best wide receivers in fantasy football. He's recorded four touchdowns over that span -- including three in the past two weeks -- and has only finished with fewer than 77 receiving yards once. He's Justin Herbert's favorite target and figures to have another big outing against the lowly Texans this week.

9. Marquise Brown, Baltimore Ravens (at Bengals)

• 2021 stats: 80 receptions, 909 yards, 6 touchdowns

Marquise Brown has fallen off a bit from his strong start to the 2021 season, but the speedy wideout was still able to haul in 10 catches last week against Green Bay. Brown has an interesting matchup this week in Cincinnati against a defense he posted 80 yards and a touchdown against earlier this year. Start Brown this week.

10. Stefon Diggs, Buffalo Bills (at Patriots)

• 2021 stats: 82 receptions, 1,007 yards, 8 touchdowns

Stefon Diggs was shadowed by Panthers cornerback Stephin Gilmore last week but still managed to haul in four catches for 35 yards and a touchdown. This week, expect Diggs to see a lot of Patriots cornerback J.C. Jackson, another talented defensive back. However, Diggs has gotten the better of Jackson in the past and Buffalo badly needs to win Sunday's game. Expect Diggs to be a major part of Buffalo's game plan this week against New England.

11. D.J. Moore, Carolina Panthers (vs. Buccaneers)

• 2021 stats: 78 receptions, 986 yards, 4 touchdowns

12. Hunter Renfrow, Las Vegas Raiders (vs. Broncos)

• 2021 stats: 89 receptions, 909 yards, 5 touchdowns

13. Adam Thielen, Minnesota Vikings (vs. Rams)

• 2021 stats: 64 receptions, 686 yards, 10 touchdowns

14. Mike Evans, Tampa Bay Buccaneers (at Panthers)

• 2021 stats: 64 receptions, 899 yards, 11 touchdowns

15. Jaylen Waddle, Miami Dolphins (at Saints)

• 2021 stats: 86 receptions, 849 yards, 4 touchdowns

16. Ja'Marr Chase, Cincinnati Bengals (vs. Ravens)

• 2021 stats: 61 receptions, 1,038 yards, 10 touchdowns

17. Tyler Lockett, Seattle Seahawks (vs. Bears)

• 2021 stats: 62 receptions, 1,023 yards, 5 touchdowns

18. Michael Pittman Jr., Indianapolis Colts (at Cardinals)

• 2021 stats: 68 receptions, 889 yards, 5 touchdowns

19. DK Metcalf, Seattle Seahawks (vs. Bears)

• 2021 stats: 62 receptions, 805 yards, 8 touchdowns

20. A.J. Brown, Tennessee Titans (vs. 49ers)

• 2021 stats: 46 receptions, 615 yards, 3 touchdown

All stats via FantasyPros